{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:39:54Z","timestamp":1761489594158},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We aim to report the outcome of patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy (<jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content>) and adjuvant hemithoracic radiotherapy with or without chemotherapy at a single <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2004 and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2013, 53 patients were referred for radiation treatment following <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content>, of whom 49 were suitable for adjuvant treatment. Radiation treatment initially involved a 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> conformal, mixed electron\/photon technique, delivering 45\u201350.4\u2009Gy in 25\u201328 fractions (31 patients) and subsequently a nine\u2010field intensity\u2010modulated radiotherapy technique, delivering 50.4\u201354\u2009Gy in 28\u201330 fractions (18 patients). Fifty\u2010five per cent of patients also received pre\u2010operative chemotherapy. We assessed toxicity, disease\u2010specific and overall survival in patients who commenced radiation treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients (84%) completed treatment as prescribed. Six patients stopped prematurely due to toxicity, and two with disease progression. Most patients discontinuing due to toxicity received over 90% of the prescribed dose. Common acute toxicities included nausea, fatigue, anorexia and dermatitis. Severe early toxicities were rare. Late toxicities were uncommon, with the exception of a persistent elevation in liver enzymes in those with right\u2010sided disease. Neither clinical hepatitis nor radiation pneumonitis was documented. With a median follow up of 18.7 months, median disease\u2010free and overall survival were 21.6 and 30.5 months, respectively, and 2\u2010year overall survival was 57.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hemithoracic radiotherapy following <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content>, although associated with significant early toxicity, is well tolerated. Most patients complete the prescribed treatment, and clinically significant late toxicities are rare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12291","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T13:08:57Z","timestamp":1425647337000},"page":"355-362","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hemithoracic radiation therapy after extrapleural pneumonectomy for malignant pleural mesothelioma: Toxicity and outcomes at an <scp>A<\/scp>ustralian institution"],"prefix":"10.1111","volume":"59","author":[{"given":"Andrej","family":"Bece","sequence":"first","affiliation":[{"name":"Radiation Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"},{"name":"Radiation Oncology Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo 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