{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:37:17Z","timestamp":1769150237070,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) is useful for detecting joint inflammation and damage in the inflammatory arthropathies. This study aimed to investigate <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> cartilage damage and its associations with joint inflammation in patients with gout compared with a group with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with gout and 38 with seropositive <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> underwent 3T\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> of the wrist with assessment of cartilage damage at six carpal sites, using established scoring systems. Synovitis and bone oedema (<jats:styled-content style=\"fixed-case\">BME<\/jats:styled-content>) were graded according to <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>heumatoid <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rthritis <jats:styled-content style=\"fixed-case\">MRI S<\/jats:styled-content>coring <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem criteria. Cartilage damage was compared between the groups adjusting for synovitis and disease duration using logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, there were fewer sites of cartilage damage and lower total damage scores in the gout group (<jats:italic>P<\/jats:italic>\u2009=\u20090.02 and 0.003), adjusting for their longer disease duration and lesser degree of synovitis. Cartilage damage was strongly associated with synovitis in both conditions (R\u2009=\u20090.59, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 and R\u2009=\u20090.52, <jats:italic>P<\/jats:italic>\u2009=\u20090.0045 respectively) and highly correlated with <jats:styled-content style=\"fixed-case\">BME<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> (R\u2009=\u20090.69, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) but not in gout (R\u2009=\u20090.095, <jats:italic>P<\/jats:italic>\u2009=\u20090.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cartilage damage is less severe in gout than in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, with fewer sites affected and lower overall scores. It is associated with synovitis in both diseases, likely indicating an effect of pro\u2010inflammatory cytokine production on cartilage integrity. However, the strong association between cartilage damage and <jats:styled-content style=\"fixed-case\">BME<\/jats:styled-content> observed in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> was not identified in gout. This emphasizes differences in the underlying pathophysiology of joint damage in these two conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12306","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T10:13:52Z","timestamp":1429784032000},"page":"431-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A comparative <scp>MRI<\/scp> study of cartilage damage in gout versus rheumatoid arthritis"],"prefix":"10.1111","volume":"59","author":[{"given":"Ivor","family":"Popovich","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Pathology University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arier CL","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Tamaki Campus University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Radiology Auckland District Health Board Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"McHaffie","sequence":"additional","affiliation":[{"name":"Department of Radiology Auckland District Health Board Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Radiology Auckland District Health Board Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of Radiology Auckland District Health Board Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"Bone &amp; Joint Research Group Department of Medicine University of Auckland  Auckland New Zealand"},{"name":"Department of Rheumatology Auckland District Health Board Greenlane Clinical Centre  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona M","family":"McQueen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Pathology University of Auckland  Auckland New Zealand"},{"name":"Department of Rheumatology Auckland District Health Board Greenlane Clinical Centre  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1385","article-title":"OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. 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