{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:34:20Z","timestamp":1778672060187,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Image\u2010based brachytherapy for cervical cancer using <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> has been implemented in Australia and New Zealand. The aims of this study were to measure variability in High\u2010risk <jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content>) delineation and evaluate dosimetric consequences of this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine radiation oncologists, one radiation therapist and two radiologists contoured <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> on 3T <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> datasets from ten consecutive patients undergoing cervical brachytherapy at a single institution. Contour comparisons were performed using the Dice Similarity Coefficient (<jats:styled-content style=\"fixed-case\">DSC<\/jats:styled-content>) and Mean Absolute Surface Distance (<jats:styled-content style=\"fixed-case\">MASD<\/jats:styled-content>). Two reference contours were created for brachytherapy planning: a Simultaneous Truth and Performance Level Estimation (<jats:styled-content style=\"fixed-case\">STAPLE<\/jats:styled-content>) and a consensus contour (<jats:styled-content style=\"fixed-case\">CONSENSUS<\/jats:styled-content>). Optimized plans (8\u00a0Gy) for both these contours were applied to individual participant's contours to assess D90 and D100 coverage of <jats:styled-content style=\"fixed-case\">HR CTV<\/jats:styled-content>. To compare variability in dosimetry, relative standard deviation (<jats:styled-content style=\"fixed-case\">rSD<\/jats:styled-content>) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Good concordance (mean <jats:styled-content style=\"fixed-case\">DSC<\/jats:styled-content>\u22650.7, <jats:styled-content style=\"fixed-case\">MASD<\/jats:styled-content>\u22645\u00a0mm) was achieved in 8\/10 cases when compared to the <jats:styled-content style=\"fixed-case\">STAPLE<\/jats:styled-content> reference and 6\/10 cases when compared to the <jats:styled-content style=\"fixed-case\">CONSENSUS<\/jats:styled-content> reference. Greatest variation was visually seen in the cranio\u2010caudal direction. The average mean <jats:styled-content style=\"fixed-case\">rSD<\/jats:styled-content> across all patients was 27% and 34% for the <jats:styled-content style=\"fixed-case\">STAPLE HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> D90 and D100, respectively, and 28% and 35% for the <jats:styled-content style=\"fixed-case\">CONSENSUS HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> D90 and D100. Delineation uncertainty resulted in an average dosimetric uncertainty of \u00b11.5\u20131.6\u00a0Gy per fraction based on an 8\u00a0Gy prescribed fraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Delineation of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> for cervical cancer brachytherapy was consistent amongst observers, suggesting similar interpretation of <jats:styled-content style=\"fixed-case\">GEC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ESTRO<\/jats:styled-content> guidelines. Despite the good concordance, there was dosimetric variation noted, which could be clinically significant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12509","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T06:33:03Z","timestamp":1471329183000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010risk <scp>CTV<\/scp> delineation for cervix brachytherapy: Application of <scp>GEC<\/scp>\u2010<scp>ESTRO<\/scp> guidelines in Australia and New Zealand"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-6219","authenticated-orcid":false,"given":"Shalini K","family":"Vinod","sequence":"first","affiliation":[{"name":"Cancer Therapy Centre Liverpool Hospital Liverpool New South Wales Australia"},{"name":"South Western Sydney Clinical School University of NSW Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Lim","sequence":"additional","affiliation":[{"name":"Cancer Therapy Centre Liverpool Hospital Liverpool New South Wales Australia"},{"name":"South Western Sydney Clinical School University of NSW Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Bell","sequence":"additional","affiliation":[{"name":"Centre for Medical Radiation Physics University of Wollongong Wollongong New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research Liverpool Hospital Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Veera","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Ohanessian","sequence":"additional","affiliation":[{"name":"Cancer Therapy Centre Liverpool Hospital Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Juresic","sequence":"additional","affiliation":[{"name":"Cancer Therapy Centre Liverpool Hospital Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nira","family":"Borok","sequence":"additional","affiliation":[{"name":"Department of Radiology Liverpool Hospital Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Royal Brisbane &amp; Women's Hospital Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Chee","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care Perth Western Australia Australia"},{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet","family":"Do","sequence":"additional","affiliation":[{"name":"Crown Princess Mary Cancer Centre Westmead Hospital Westmead New South Wales Australia"},{"name":"Nepean Clinical School University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Govindarajulu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Calvary Mater Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetha","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Calvary Mater Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Johnson","sequence":"additional","affiliation":[{"name":"Wellington Blood &amp; Cancer Centre Wellington Hospital Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moses","sequence":"additional","affiliation":[{"name":"School of Medicine University of NSW Sydney New South Wales Australia"},{"name":"Department of Radiology Prince of Wales Hospital Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Van Dyk","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois","family":"Holloway","sequence":"additional","affiliation":[{"name":"Cancer Therapy Centre Liverpool Hospital Liverpool New South Wales Australia"},{"name":"South Western Sydney Clinical School University of NSW Sydney New South Wales Australia"},{"name":"Centre for Medical Radiation Physics University of Wollongong Wollongong New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research Liverpool Hospital Liverpool New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.11.014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.10.023"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.01.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2004.828354"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.12.017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2008.02025.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2010.02185.x"},{"key":"e_1_2_6_10_1","first-page":"629","article-title":"Patterns of practice for cervix cancer brachytherapy in Australia and New Zealand","volume":"24","author":"Lim K","year":"2014","journal-title":"Intl J Gynaecol Cancer"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-011-0027-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.05.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.06.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.03.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00185-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.08.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2014.42022"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:57:28Z","timestamp":1695560248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,16]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/1754-9485.12509"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12509","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,16]]},"assertion":[{"value":"2016-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}