{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T21:38:11Z","timestamp":1771796291120,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["143\u201079697L"],"award-info":[{"award-number":["143\u201079697L"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) and some chemotherapy regimens are known risk factors predisposing to the development of premature arterial disease. Vascular ultrasound measurement of carotid intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) is a non\u2010invasive technique, useful to detect early subclinical symptoms of atherosclerosis that can appear in the paediatric population. We analysed the influence of chemotherapy and moderate doses of head or neck irradiation in childhood cancer survivors on the possibility of premature carotid artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ultrasound measurements of the intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) in\u00a0the common carotid artery (<jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content>), bulb and internal carotid artery (<jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>) were performed in 74 young cancer survivors and in 48 age\u2010 and sex\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the whole study group, we observed higher <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> in all positions as compared with the control, except for comparable thickness in the <jats:styled-content style=\"fixed-case\">CCA<\/jats:styled-content> (bilaterally). We failed to find any differences in <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> between irradiated and non\u2010irradiated females. In irradiated males, all <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> measurements on the right side were higher than in non\u2010irradiated patients. There was no effect of body mass index, blood pressure, serum cholesterol, triglycerides, fibrinogen and thyroid hormones on <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>. In the irradiated group, a positive correlation was observed between <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> in the right bulb and the post\u2010radiation time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anticancer treatment during childhood, especially including irradiation to the mediastinum, head or neck, affects the <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>, particularly in males. This suggests a possible role of irradiation in the premature development of carotid artery disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12510","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T04:02:46Z","timestamp":1472011366000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Carotid intima\u2010media thickness in young survivors of childhood cancer"],"prefix":"10.1111","volume":"61","author":[{"given":"Maryna","family":"Krawczuk\u2010Rybak","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Tomczuk\u2010Ostapczuk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Medical University of Bialystok Children's Clinical Hospital of L. 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