{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:53:22Z","timestamp":1775714002582,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We assess the ability of low\u2010dose hybrid iterative reconstruction (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) and \u2018pure\u2019 model\u2010based <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MBIR<\/jats:styled-content>) images to maintain accurate Hounsfield unit (<jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content>)\u2010determined tissue characterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Standard\u2010protocol (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) and low\u2010dose modified\u2010protocol (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>s were contemporaneously acquired in 34 Crohn's disease patients referred for <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> image reconstruction was via the manufacturer's recommendations (60% <jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content>, filtered back projection; 40% <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR, Adaptive Statistical iterative Reconstruction; <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR40). <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> data sets underwent four reconstructions (100% <jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content>; 40% <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR; 70% <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR; <jats:styled-content style=\"fixed-case\">MBIR<\/jats:styled-content>). Three observers measured tissue volumes using <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> thresholds for fat, soft tissue and bone\/contrast on each data set. Analysis was via <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010observer agreement was strong for 1530 datapoints (<jats:italic>rs\u00a0<\/jats:italic>&gt;\u00a00.9). <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBIR<\/jats:styled-content> tissue volume measurement was superior to other <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> reconstructions and closely correlated with the reference <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR40 images for all tissue types. <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBIR<\/jats:styled-content> superiority was most marked for fat volume calculation \u2013 close <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR40 and <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBIR<\/jats:styled-content> Bland\u2013Altman plot correlation was seen with the lowest average difference (336\u00a0cm<jats:sup>3<\/jats:sup>) when compared with other <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> reconstructions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hounsfield unit\u2010determined tissue volume calculations from <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MBIR<\/jats:styled-content> images resulted in values comparable to <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR40 calculations and values that are superior to <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>iR images. Accuracy of estimation of volume of tissues (e.g. fat) using segmentation software on low\u2010dose <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> images appears optimal when reconstructed with pure <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12546","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T04:07:20Z","timestamp":1476418040000},"page":"190-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Accurate tissue characterization in low\u2010dose <scp>CT<\/scp> imaging with pure iterative reconstruction"],"prefix":"10.1111","volume":"61","author":[{"given":"Kevin P","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick D","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u200eMaria","family":"Twomey","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent E","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiachra","family":"Moloney","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faimee E","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tafline","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhan B","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen J","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M","family":"Maher","sequence":"additional","affiliation":[{"name":"Department of Radiology University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60815-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2012-101037"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/01948454"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072149"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.2.1760289"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.11.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.151415"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181e5d1c5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090094"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0471"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2331031505"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2322031304"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2371041227"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2858-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9382"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10092212"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2011.07.001"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8986"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2186-3"},{"key":"e_1_2_5_21_1","first-page":"459","article-title":"Nobel lecture, 8 December 1979. 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