{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:30:37Z","timestamp":1761823837286,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gemistocytic astrocytoma is the second most common subtype of World Health Organization grade 2 astrocytoma, but has a worse prognosis than other grade 2 lesions. We aim to describe the <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging features of histopathologically proven gemistocytic tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ethics approval was obtained from both institutions. Patient consent was not required for this retrospective study. We reviewed <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging findings of 16 consecutive cases of histopathologically proven gemistocytic astrocytoma and anaplastic astrocytoma with gemistocytic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average patient age was 48\u00a0years, with a 3:1 male to female ratio. Based on our series, the typical appearance of a gemistocytic astrocytoma is a large, heterogeneous mass most commonly supratentorial and lobar. Regions of cyst formation, partial signal suppression on <jats:styled-content style=\"fixed-case\">FLAIR<\/jats:styled-content> images and contrast enhancement are all common features. Additionally, contrary to previous literature that describes gemistocytic astrocytoma as a purely supratentorial lesion, we present two cases of gemistocytic astrocytoma involving the brainstem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The possibility of gemistocytic astrocytoma should be considered in patients presenting with large heterogeneous tumours that have regions of cyst formation, partial <jats:styled-content style=\"fixed-case\">FLAIR<\/jats:styled-content> suppression and contrast enhancement. This may be especially useful in reconciling a lesion with high\u2010grade <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging features with low\u2010grade histopathology. An infratentorial location does not preclude the diagnosis of gemistocytic astrocytoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12550","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T08:42:57Z","timestamp":1477039377000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnetic resonance imaging features of gemistocytic astrocytoma"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-9809","authenticated-orcid":false,"given":"Paul M","family":"Simkin","sequence":"first","affiliation":[{"name":"Department of Radiology Royal Melbourne Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Austin Hospital Melbourne Victoria 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