{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:18:28Z","timestamp":1782602308960,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anaplastic thyroid cancer is a rare and fatal malignancy, associated with significant local tumour and often treatment related morbidity. We report our experience in treating this cancer over a 20\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of prospectively collected data from a single Australian Institution (Alfred Health Radiation Oncology) was carried out on patients referred with anaplastic thyroid carcinoma between 1992 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (17 females and 13 males) were identified with a median age at presentation of 72\u00a0years. At presentation, six (20%), 14 (47%) and 10 (33%) patients had stage <jats:styled-content style=\"fixed-case\">IVA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IVB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IVC<\/jats:styled-content> disease respectively. Thirteen patients underwent radical surgical resection with five having microscopic residual (R1) and eight having macroscopic residual (R2) disease. Twenty\u2010eight patients were offered radiotherapy with 27 proceeding with treatment. Of those who received radiotherapy, three, six and 18 were treated with adjuvant, definitive and palliative intent respectively. Six patients had concomitant chemotherapy of which three received trimodality therapy. Only one patient experienced a grade 3 toxicity (oesophagitis). Median survival was 5.3\u00a0months and at last follow\u2010up or time of death, 19 of 27 (70.4%) maintained loco\u2010regional control. All patients who had R1 surgical resections and radiotherapy had loco\u2010regional control. Seven of nine (77.8%) and 12 of 18 (66.7%) achieved loco\u2010regional control after receiving definitive or palliative radiotherapy, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that radiotherapy with or without surgery or chemotherapy is well\u2010tolerated and results in durable loco\u2010regional control in a high proportion of patients with anaplastic thyroid carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12552","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T06:53:28Z","timestamp":1478501608000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Radiotherapy in anaplastic thyroid carcinoma: An Australian experience"],"prefix":"10.1111","volume":"61","author":[{"given":"Kevin","family":"So","sequence":"first","affiliation":[{"name":"Alfred Health Radiation Oncology The Alfred Prahran Victoria Australia"},{"name":"Epworth Health Richmond Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin E","family":"Smith","sequence":"additional","affiliation":[{"name":"Alfred Health Radiation Oncology The Alfred Prahran Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney R","family":"Davis","sequence":"additional","affiliation":[{"name":"Alfred Health Radiation Oncology The Alfred Prahran Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.02.016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008322002520"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0302"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199901\/02)16:1<64::AID-SSU10>3.0.CO;2-U"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3108-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28187"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2004.03062.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3545-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-90"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0004"},{"key":"e_1_2_5_13_1","first-page":"261","article-title":"Thyroid anaplastic carcinoma: the impact of multimodality treatment on survival. 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