{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:19:27Z","timestamp":1773163167650,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Prostate specific membrane antigen (PSMA<\/jats:styled-content>) positron emission tomography (PET<\/jats:styled-content>) is an emerging imaging modality in prostate cancer. However, 68<\/jats:sup>Ga\u2010PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content> may also have diagnostic utility in the setting of renal cell carcinoma (RCC<\/jats:styled-content>). We investigate the differential role of 18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG<\/jats:styled-content>) and PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> scanning in patients with oligometastatic RCC<\/jats:styled-content>. In particular, we focus on the utility of PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content> for diagnostic evaluation of isolated or limited metastases planned for local surgery or radiation, as well as the potential utility of PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content> for therapeutic response assessment in patients receiving stereotactic ablative body radiotherapy (SABR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We present a retrospective series of eight patients in which comparative imaging modalities are evaluated against PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content> scanning. FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content> and PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content> scans were performed prior to definitive treatment (either surgery or SABR<\/jats:styled-content>) of limited recurrent disease. Response assessment after SABR<\/jats:styled-content> was performed with both PET<\/jats:styled-content> imaging modalities at multiple time points in a subset of four patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Prostate specific membrane antigen uptake is typically more intense than FDG<\/jats:styled-content> in RCC<\/jats:styled-content>. In all but two cases, one of which was papillary carcinoma, FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content> and PSMA<\/jats:styled-content>\u2010PET<\/jats:styled-content> are concordant for detection of sites of disease. We demonstrate for the first time the differential kinetics of post\u2010treatment response using PSMA<\/jats:styled-content> and FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>, with a more rapid metabolic response observed on FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>. Both modalities demonstrate response earlier than morphological appearances on CT<\/jats:styled-content> or MRI<\/jats:styled-content> imaging.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our series suggests that PSMA<\/jats:styled-content> shows early promise as a diagnostic and therapeutic response assessment tool in patients with metastatic RCC<\/jats:styled-content> receiving definitive local therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12590","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T06:35:14Z","timestamp":1485239714000},"page":"372-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Utility of 68<\/sup>Ga prostate specific membrane antigen \u2013 positron emission tomography in diagnosis and response assessment of recurrent renal cell carcinoma"],"prefix":"10.1111","volume":"61","author":[{"given":"Shankar","family":"Siva","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Callahan","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pryor","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarad","family":"Martin","sequence":"additional","affiliation":[{"name":"Calvary Mater Hospital Waratah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lawrentschuk","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S","family":"Hofman","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.03.025"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.40"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001128"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2766-y"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-015-1017-z"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.939298"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.0042"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc700341x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2013-0067"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980715)83:2<344::AID-CNCR19>3.0.CO;2-T"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1027409"}],"container-title":["Journal 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