{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:29:43Z","timestamp":1748993383351},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,19]],"date-time":"2017-02-19T00:00:00Z","timestamp":1487462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The segmentation and skeletonisation of images via computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) airway lumen volumetry provide a new perspective regarding the incorporation of this technique in medical practice. Our aim was to quantify morphological changes in the large airways of patients with acromegaly through <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and, secondarily, to correlate these findings with hormone levels and pulmonary function testing (<jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>) parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study in which 28 non\u2010smoker patients with acromegaly and 15 control subjects underwent <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> analysis of airway lumen volumetry with subsequent image segmentation and skeletonisation. Moreover, all participants were subjected to <jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the controls, patients with acromegaly presented higher diameters in the trachea, right main bronchus and left main bronchus. The patients with acromegaly also showed a higher tracheal sinuosity index (the deviation of a line from the shortest path, calculated by dividing total length by shortest possible path) than the controls [1.06 (1.02\u20131.09) vs. 1.03 (1.02\u20131.04), <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04], and tracheal stenosis was observed in 25% of these individuals. The tracheal area was correlated with the levels of growth hormone (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.45, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02) and insulin\u2010like growth factor type I (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.38, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04). The ratio between the forced expiratory flow and forced inspiratory flow at 50% of the forced vital capacity was correlated with the tracheal area (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.36, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02) and \u0394 tracheal diameters (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.58, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with acromegaly exhibit tracheobronchomegaly and tracheal sinuosity\/stenosis. Moreover, there are associations between the results of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> airway lumen volumetry, hormone levels and functional parameters of large airway obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12598","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T04:42:45Z","timestamp":1487565765000},"page":"591-599","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Computed tomography airway lumen volumetry in patients with acromegaly: Association with growth hormone levels and lung function"],"prefix":"10.1111","volume":"61","author":[{"given":"Gustavo Bittencourt","family":"Camilo","sequence":"first","affiliation":[{"name":"Postgraduate Programme in Medical Sciences, School of Medical Sciences State University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Faculty of Medical and Health Sciences of Juiz de Fora 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