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Currently, the diagnosis is based upon the National Institute of Neurological Disorders and Stroke and the Society for <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> criteria. These criteria consist of purely clinical findings. Elements of brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> that are being investigated for this role include identifying structural features on conventional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, volume changes, signal abnormalities and diffusion changes. The aim of this study is to conduct a systematic search to identify which <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings have evidence to support their sensitivity\/specificity\/accuracy in the diagnosis of <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. A search was conducted of Pubmed and Medline on July 5th\u20136th 2016 using the medical subject headings <jats:italic>progressive supranuclear palsy<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content><\/jats:italic>. Seventy articles were identified which assessed the sensitivity\/specificity\/accuracy of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> signs for the diagnosis of <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. There were 13 studies that identified <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> features that had \u226595% sensitivity and specificity for the diagnosis of <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. Four of these studies identified the magnetic resonance parkinsonism index as highly sensitive and specific. There were only four studies which assessed how effective given <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> features are at predicting the pathological diagnosis of <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. Several markers, such as the magnetic resonance parkinsonism index, have been demonstrated to be both specific and sensitive for <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. However, many studies assessing these markers have common weaknesses including small sample size and lacking autopsy correlation.<\/jats:p>","DOI":"10.1111\/1754-9485.12613","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T07:03:15Z","timestamp":1492844595000},"page":"21-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Specificity and sensitivity of magnetic resonance imaging findings in the diagnosis of progressive supranuclear palsy"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"first","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Chim","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia 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