{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:43:17Z","timestamp":1790505797685,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["IRG 5780016"],"award-info":[{"award-number":["IRG 5780016"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Causes of orbital masses can be either benign or malignant. An <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> with diffusion\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) may be helpful to differentiate causes of orbital masses. This study aimed to evaluate the diagnostic properties of an apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) in orbital masses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed patients with orbital masses who underwent <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> and had histopathological results. Orbital lesions were categorized as benign or malignant and compared with respect to the <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> ratio. A receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) was plotted to evaluate the sensitivity and specificity of the <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> ratio threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of all 42 patients in this study was 36.31\u00a0years (S.D. 22.12) and 26 of the patients were male (61.9%). The malignant orbital masses accounted for 43% (18 patients). The most common cell type was meningioma (10 patients; 23.8%). There was no statistical difference between the <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values of benign and malignant tumours (1.18 vs 0.99 \u00d710<jats:sup>\u22123<\/jats:sup>\u00a0mm<jats:sup>2<\/jats:sup>\/s; <jats:italic>P<\/jats:italic>\u2010value 0.200). The myxoid tumours had significantly higher <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values than the non\u2010myxoid (1.58 vs 0.99; <jats:italic>P<\/jats:italic>\u2010value 0.008) tumours. Non\u2010metastatic non\u2010myxoid tumours also had significantly lower <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values than metastatic non\u2010myxoid tumours (0.73 vs 1.32; <jats:italic>P<\/jats:italic>\u2010values 0.006). The <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> cut\u2010off point of greater than or equal to 0.95\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>\u00a0mm<jats:sup>2<\/jats:sup>\/s was given a sensitivity of 87.50% for myxoid orbital masses, while the cut\u2010off point of greater than or equal to 1.01\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>\u00a0mm<jats:sup>2<\/jats:sup>\/s was given a sensitivity of 80.00% for metastatic, non\u2010myxoid malignant orbital masses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Benign and malignant orbital masses cannot be distinguished by using the <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values. However, the <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values were useful in differentiating between myxoid vs non\u2010myxoid orbital masses and metastatic non\u2010myxoid vs non\u2010metastatic non\u2010myxoid orbital masses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12627","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T06:56:44Z","timestamp":1498805804000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The roles of the diffusion\u2010weighted imaging in orbital masses"],"prefix":"10.1111","volume":"61","author":[{"given":"Warinthorn","family":"Phuttharak","sequence":"first","affiliation":[{"name":"Department of Radiology Faculty of Medicine Khon Kaen University Khon Kaen 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