{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:03:48Z","timestamp":1792670628456,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1003895"],"award-info":[{"award-number":["APP1003895"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute radiation oesophagitis (<jats:styled-content style=\"fixed-case\">ARO<\/jats:styled-content>) is frequently experienced by patients receiving concurrent chemo\u2010radiation therapy (<jats:styled-content style=\"fixed-case\">cCRT<\/jats:styled-content>) for non\u2010small\u2010cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>). We investigated <jats:styled-content style=\"fixed-case\">ARO<\/jats:styled-content> symptoms (<jats:styled-content style=\"fixed-case\">CTCAE<\/jats:styled-content> v3.0), radiation dose and oesophageal <jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Candidates received <jats:styled-content style=\"fixed-case\">cCRT<\/jats:styled-content> (60\u00a0Gy, 2\u00a0Gy\/fx) and sequential <jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> (baseline <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>0<\/jats:sub>, <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk2<\/jats:sub> and <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk4<\/jats:sub>). Mean and maximum standardized uptake value (<jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>mean and <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max) and radiation dose (<jats:italic>O<\/jats:italic><jats:sub>mean<\/jats:sub> and <jats:italic>O<\/jats:italic><jats:sub>max<\/jats:sub>) were calculated within the whole oesophagus and seven sub\u2010regions (5\u201360\u00a0Gy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four patients underwent <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>0<\/jats:sub> and <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk2<\/jats:sub>, and 41 (93%) received <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk4<\/jats:sub>, resulting in 129 <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans for analysis. Of 29 (66%) patients with \u2265 grade 2 <jats:styled-content style=\"fixed-case\">ARO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SUV<\/jats:styled-content>max (mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) increased from <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>0<\/jats:sub> to <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk4<\/jats:sub> (3.06\u00a0\u00b1\u00a00.69 to 3.83\u00a0\u00b1\u00a01.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0019) and <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk2<\/jats:sub> to <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk4<\/jats:sub> (3.10\u00a0\u00b1\u00a00.75 to 3.83\u00a0\u00b1\u00a01.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0046). Radiation dose (mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) was higher in grade \u22652 patients; <jats:italic>O<\/jats:italic><jats:sub>mean<\/jats:sub> (47.5\u00a0\u00b1\u00a020 vs 53.9\u00a0\u00b1\u00a010.2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0061), <jats:italic>O<\/jats:italic><jats:sub>max<\/jats:sub> (13.7\u00a0\u00b1\u00a09.6 vs 20.1\u00a0\u00b1\u00a010.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0009) and V40\u00a0Gy (8.0\u00a0\u00b1\u00a08.2 vs 11.9\u00a0\u00b1\u00a07.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0185).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content><jats:sub>wk4<\/jats:sub> <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max and radiation dose were associated with \u2265 grade 2 <jats:styled-content style=\"fixed-case\">ARO<\/jats:styled-content>. Compared to subjective assessments, future interim <jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> acquired for disease response assessment may also be utilized to objectively characterize <jats:styled-content style=\"fixed-case\">ARO<\/jats:styled-content> severity and image\u2010guided oesophageal dose constraints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12631","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T07:06:49Z","timestamp":1497337609000},"page":"682-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute radiation oesophagitis associated with 2\u2010deoxy\u20102\u2010[18F]fluoro\u2010<scp>d<\/scp>\u2010glucose uptake on positron emission tomography\/<scp>CT<\/scp> during chemo\u2010radiation therapy in patients with non\u2010small\u2010cell lung cancer"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-0067","authenticated-orcid":false,"given":"Sarah","family":"Everitt","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia"},{"name":"Department of Medical Imaging &amp; Radiation Sciences Faculty of Medicine, Nursing &amp; Health Sciences Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Callahan","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging &amp; Radiation Sciences Faculty of Medicine, Nursing &amp; Health Sciences Monash University Clayton Victoria Australia"},{"name":"Centre for Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Obeid","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J","family":"Hicks","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia"},{"name":"Centre for Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mac Manus","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-6919","authenticated-orcid":false,"given":"David","family":"Ball","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.03.021"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00699-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90371-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs056"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.064"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.04.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2011.03.026"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(99)00089-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.03.014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.255045122"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2004.07.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.04.021"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2579-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00031-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.05.070"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0111-RS"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00238"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.10.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-37"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.09.024"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-016-0596-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.07.012"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:13:14Z","timestamp":1696043594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/1754-9485.12631"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12631","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,13]]},"assertion":[{"value":"2016-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}