{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:04:04Z","timestamp":1788930244298,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to analyse the value of diffusion\u2010weighted magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) to determine the liver parenchyma iron concentration in \u03b2\u2010thalassaemia major patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Abdominal magnetic resonance (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) imaging, including gradient echo sequences and <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> sequences, was undertaken of 55 \u03b2\u2010thalassaemia major patients. The apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) values of liver parenchyma were measured in seven regions at the level of the portal bifurcation and compared with liver iron concentration (<jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>). Patients with normal and mild liver dry weight (<jats:styled-content style=\"fixed-case\">LDW<\/jats:styled-content>) results were classified as group 1, whereas patients with moderate and severe values were classified as group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a dramatic decrease in <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values as the severity of <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content> increased. The median <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> values were 1.6\u20131.9\u00a0\u00d7\u00a010<jats:sup>\u22123\u00a0<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/sec in group 1 and 0.6\u20130.9\u00a0\u00d7\u00a010<jats:sup>\u22123\u00a0<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/sec in group 2. A negative correlation was observed between <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">LDW<\/jats:styled-content> values in both groups. The <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content> correlation in each subgroup was statistically significant with asymptotic 95% confidence intervals of 0.820\u20130.997.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diffusion\u2010weighted imaging is sensitive to tissue changes as a result of iron accumulation and may be used to predict liver iron overload in \u03b2\u2010thalassaemia major patients with a high sensitivity and specificity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12639","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T07:06:42Z","timestamp":1499756802000},"page":"169-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of diffusion\u2010weighted imaging in prediction liver iron concentration in beta\u2010thalassaemia 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