{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:44:12Z","timestamp":1740149052232,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To compare outcomes of different salvage treatment modalities in patients with aggressive B\u2010cell non\u2010Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) who remain <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> positive after R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> chemotherapy. Existing data on these patients with <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> primary refractory disease are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with diffuse large B\u2010cell lymphoma or grade 3 follicular lymphoma were retrospectively reviewed from the Prince of Wales Hospital databases. Eligibility criteria were: age\u226518\u00a0years, treated with R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>, with positive post\u2010chemotherapy <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>. Salvage treatment modalities were: radical radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, dose\u226530\u00a0Gy), high dose chemotherapy and autologous stem cell transplant (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>), or non\u2010radical management. Survival was calculated from date of post\u2010chemotherapy <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> to last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients from 2003\u20132015 met the inclusion criteria. Median age was 60 (range 19\u201384). Most had adverse baseline features: 21 (81%) stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, 24 (92%) bulky disease and nine (35%) skeletal involvement. Characteristics of <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010positivity post\u2010chemotherapy were single site in 16 (62%), sites of prior bulk in 24 of 24, skeletal sites in five of nine, and able to be encompassed by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> in 21 (81%). Salvage treatment was: radical <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> in 17 (65%), <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> in four (15%) and non\u2010radical in five (20%). Median follow\u2010up of surviving patients was 31\u00a0months. Kaplan\u2013Meier estimates of 3\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> were 41% and 52%, respectively. By salvage modality, 3\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> was 51% for <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, 25% for <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> and 20% for non\u2010radical treatment, (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.453); 3\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was respectively 65%, 25% and 40% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.173).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> positive disease after R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> for aggressive B\u2010cell <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> are salvageable with radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12719","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T05:49:28Z","timestamp":1522043368000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of salvage treatment modalities in patients with positive FDG\u2010PET\/CT after R\u2010CHOP chemotherapy for aggressive B\u2010cell non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-1243","authenticated-orcid":false,"given":"Vicky","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Prince of Wales Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fulham","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging (PET and Nuclear 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Australia"},{"name":"University of New South Wales Sydney New South Wales Australia"},{"name":"NSW Health Pathology Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Brighton","sequence":"additional","affiliation":[{"name":"Department of Haematology Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Kidson\u2010Gerber","sequence":"additional","affiliation":[{"name":"Department of Haematology Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva A","family":"Wegner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Prince of Wales Hospital Sydney New South Wales 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