{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:22:19Z","timestamp":1754396539800,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The clinical target volume (<jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content>) delineation is crucial for tumour control and normal tissue protection. This study investigated the contralateral extension of nasopharyngeal carcinoma (<jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>) in patients with a clinically diagnosed unilateral tumour to pursue the possibility of <jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> patients with localized tumours confined to only one side of the nasopharynx as shown by magnetic resonance imaging and fibreoptic endoscopy were selected for biopsy. The tissues of the contralateral pharyngeal recess (<jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>) and the contralateral posterosuperior wall (<jats:styled-content style=\"fixed-case\">CPSW<\/jats:styled-content>) of the nasopharynx were obtained in each case and prepared for pathological examination. The factors associated with contralateral tumour infiltration were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five of 20 (25.0%) patients were pathologically confirmed to have carcinoma cell infiltration in the <jats:styled-content style=\"fixed-case\">CPSW<\/jats:styled-content>, including 2 (10.0%) that had carcinoma cell infiltration in the <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>. The T classification (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.014) and primary tumour volume (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.033) were positively associated with the infiltration of the <jats:styled-content style=\"fixed-case\">CPSW<\/jats:styled-content>, but none of the primary tumour factors affected the involvement of the <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>. The contralateral retropharyngeal lymph node (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>) metastasis (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.016), but not the contralateral cervical <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>, was significantly associated with the infiltration of the <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>. Positive Epstein\u2013Barr virus <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>) was another factor that increased the probability of <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> invasion (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contralateral pharyngeal recess infiltration is rare in patients with clinically diagnosed unilateral primary <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>. Reduced <jats:styled-content style=\"fixed-case\">CTV<\/jats:styled-content> coverage, including the <jats:styled-content style=\"fixed-case\">CPSW<\/jats:styled-content> but not <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, is feasible for patients with unilateral cancer of the nasopharynx without contralateral <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> metastasis or positive <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. Further large\u2010sample studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12741","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T01:40:55Z","timestamp":1527558055000},"page":"540-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pathologic study of tumour extension for clinically localized unilateral nasopharyngeal carcinoma: Should the contralateral side be included in the clinical target volume?"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-7657","authenticated-orcid":false,"given":"An\u2010chuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation 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