{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:10Z","timestamp":1784127790805,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The diagnostic yield of and best approaches for imaging\u2010guided percutaneous biopsy for vertebral osteomyelitis is controversial. Early studies suggest yields of up to 90%; however, recent evidence shows lower yields of 30\u201340%. We aim to determine yield and predictors of yield in percutaneous <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u2010guided biopsies in vertebral osteomyelitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective observational single\u2010centre study cohort study of all patients presenting for vertebral biopsy or aspiration between 2014 and 2018. Only patients undergoing biopsy for suspected infection were included. Patients with malignant indications were excluded. Comprehensive review of medical records was performed for clinical presentation, comorbidities, imaging, biomarkers, microbiology and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 40 out of 88 biopsies were performed for suspected infection, in 36 patients. Mean age was 59\u00a0\u00b1\u00a018\u00a0years; 29 (81%) were male. Of the 40 samples, an organism was identified in 14 samples (35%). Gram\u2010positive organisms were most commonly identified; Staphylococcus aureus was cultured in 7 (50%) of samples. Mean admission <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was significantly higher in patients with identified organisms compared to those without (137\u00a0\u00b1\u00a0106 vs 54\u00a0\u00b1\u00a078, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Aspiration was a strong independent predictor of positive microbiological growth on multivariate analysis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.52 [1.25\u201334.02], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). Biopsy or aspiration aided clinical decision\u2010making in half of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Percutaneous <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u2010guided biopsy has a modest yield for identifying the culprit organism in suspected cases of vertebral osteomyelitis. Elevated <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and aspiration of fluid collections are associated with improved microbiological yield and should be considered in deciding when and where to biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12923","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T01:44:10Z","timestamp":1562982250000},"page":"589-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Diagnostic yield of computed tomography\u2010guided biopsy and aspiration for vertebral osteomyelitis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-2345","authenticated-orcid":false,"given":"Megan T","family":"Ang","sequence":"first","affiliation":[{"name":"Department of Radiology Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey R","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine Royal Melbourne Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davy R","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Notre Dame Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-5850","authenticated-orcid":false,"given":"Warren","family":"Clements","sequence":"additional","affiliation":[{"name":"Department of Radiology Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Radiology Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.03.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.11.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.6.FOCUS14134"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.01.125"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.1.r01ja06211"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy037"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5337"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-1051-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3120"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.2.320"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.12923","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T17:33:37Z","timestamp":1694194417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,12]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/1754-9485.12923"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12923","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,12]]},"assertion":[{"value":"2019-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}