{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:32:29Z","timestamp":1767828749068,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Identifying glioma grade through imaging allows clinicians to recommend and accurately direct treatment. We sought to quantify the utility of FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> (18F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography), alone and in combination with MRI<\/jats:styled-content>, in identifying high\u2010grade regions of glioma.<\/jats:p><\/jats:sec>Methods<\/jats:title>This is a retrospective review of patients who had an FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> performed as part of the workup of suspected glioma or in follow\u2010up of known glioma. FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> scans were reviewed and uptake in the identifiable lesion coded as none, diffusely or focally increased. Patients also underwent gadolinium\u2010enhanced MRI<\/jats:styled-content>, noting regions of contrast enhancement. Sensitivity, specificity, positive and negative predictive values (PPV<\/jats:styled-content> and NPV<\/jats:styled-content>) were calculated for identification of high\u2010grade histology (WHO III<\/jats:styled-content> or IV<\/jats:styled-content>, or metastatic disease) obtained post\u2010FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010three patients had 36 FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> and MRI<\/jats:styled-content> scans followed by histological confirmation (biopsy or debulking). Increased FDG<\/jats:styled-content> uptake demonstrated a sensitivity of 59% and specificity of 79%, PPV<\/jats:styled-content> of 81% and NPV<\/jats:styled-content> of 55% for identification of high\u2010grade histology. MRI<\/jats:styled-content> demonstrated a sensitivity of 77% and specificity of 86%, PPV<\/jats:styled-content> of 89% and NPV<\/jats:styled-content> of 71% for identification of high\u2010grade histology. Only 64% of MRI<\/jats:styled-content> and FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> scan series were concordant. When FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> and MRI<\/jats:styled-content> were concordant, a specificity of 100% and PPV<\/jats:styled-content> of 100% was achieved, however, sensitivity was 79% and NPV<\/jats:styled-content> was 75%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The combination of FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> and gadolinium\u2010enhanced MRI<\/jats:styled-content> demonstrated marked improvement in identifying potential high\u2010grade disease over each modality alone. Increased FDG<\/jats:styled-content> uptake without gadolinium enhancement rarely occurred and identified high\u2010grade histology in a small number of patients. Due to limited sensitivity and NPV<\/jats:styled-content>, a negative FDG<\/jats:styled-content>\u2010PET<\/jats:styled-content>\/CT<\/jats:styled-content> alone, or in combination with MRI<\/jats:styled-content>, should not guide a decision for observation where surgery would otherwise be recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12929","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T09:59:32Z","timestamp":1564653572000},"page":"650-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic performance of 18F\u2010fluorodeoxyglucose positron emission tomography in the evaluation of glioma"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-1156","authenticated-orcid":false,"given":"Tristan B","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Royal Brisbane and Women's Hospital Brisbane Queensland Australia"},{"name":"Griffith University Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-2694","authenticated-orcid":false,"given":"Rosalind L","family":"Jeffree","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Brisbane and Women's Hospital Brisbane Queensland Australia"},{"name":"University of Queensland St. Lucia Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Queensland St. Lucia Queensland Australia"},{"name":"Department of Nuclear Medicine Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Debowski","sequence":"additional","affiliation":[{"name":"University of Queensland St. Lucia Queensland Australia"},{"name":"Department of Nuclear Medicine Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarnie","family":"Lwin","sequence":"additional","affiliation":[{"name":"University of Queensland St. Lucia Queensland Australia"},{"name":"Department of Medical Oncology Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Royal Brisbane and Women's Hospital Brisbane Queensland Australia"},{"name":"University of Queensland St. Lucia Queensland 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