{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:26:46Z","timestamp":1784352406421,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To investigate whether the implantation of a hydrogel spacer (SpaceOAR) reduces long\u2010term rectal toxicity for prostate cancer patients treated with intensity\u2010modulated radiotherapy (IMRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with localised prostate cancer treated with 81\u00a0Gy in 45\u00a0fx of IMRT over 9\u00a0weeks were retrospectively compared: 65 patients with SpaceOAR and 56 patients without SpaceOAR. Planning aims restricted rectal doses to V40 Gy\u00a0&lt;\u00a035%, V65 Gy\u00a0&lt;\u00a017%, V75 Gy\u00a0&lt;\u00a010%. Toxicities were evaluated between 3\u00a0months and 3\u00a0years after the completion of radiotherapy and were based on the common terminology criteria for adverse events (CTCAE) assessment tool for diarrhoea, haemorrhoids, faecal incontinence and proctitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence of low\u2010grade diarrhoea (G1) was significantly higher in the non\u2010SpaceOAR group (21.4% vs 6.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016). The cumulative incidence of proctitis (grades G1 and G2) was also higher in the non\u2010SpaceOAR group (26.7% vs 9.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015); the cumulative incidence of G2 proctitis was higher in the latter group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). There were no differences between the treatment groups for cumulative incidences of faecal incontinence and\/or haemorrhoids. Three years after IMRT, diarrhoea and proctitis were higher in the non\u2010SpaceOAR group, without reaching statistical significance. This finding was unchanged after correcting for baseline symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SpaceOAR is of benefit in reducing the cumulative incidence of low\u2010grade diarrhoea and proctitis for up to 3\u00a0years after intensity\u2010modulated radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12945","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T03:54:31Z","timestamp":1568433271000},"page":"836-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Late toxicities of prostate cancer radiotherapy with and without hydrogel SpaceAOR insertion"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-816X","authenticated-orcid":false,"given":"Bridget L","family":"te Velde","sequence":"first","affiliation":[{"name":"Radiation Oncology Mid\u2010North Coast Cancer Institute Coffs Harbour New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Westhuyzen","sequence":"additional","affiliation":[{"name":"Radiation Oncology Mid\u2010North Coast Cancer Institute Coffs Harbour New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Awad","sequence":"additional","affiliation":[{"name":"Urology Centre Port Macquarie New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maree","family":"Wood","sequence":"additional","affiliation":[{"name":"Radiation Oncology Mid\u2010North Coast Cancer Institute Coffs Harbour New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P","family":"Shakespeare","sequence":"additional","affiliation":[{"name":"Radiation Oncology Mid\u2010North Coast Cancer Institute Coffs Harbour New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Australian Institute of Health and Welfare.Cancer in Australia 2017. Cancer series no 101. Cat. no. CAN 100.AIHW Canberra 2017.https:\/\/www.aihw.gov.au\/getmedia\/3da1f3c2-30f0-4475-8aed-1f19f8e16d48\/20066-cancer-2017.pdf.aspx?inline=true"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.044"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.063"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.09.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.12.019"},{"key":"e_1_2_5_7_1","unstructured":"Augmenix.\u2018Hydrogel Technology\u20192014[cited 16 Apr 2014.] Available from URL:http:\/\/www.augmenix.com\/products\/spaceoar\/hydrogel-technology\/"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12580"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2016.09.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12266"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs083"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.05.007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.07.040"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.04.030"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.12.024"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2016.05.005"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-016-1040-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v6.i6.189"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2015.12.007"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.08.026"}],"updated-by":[{"DOI":"10.1111\/1754-9485.12997","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000}}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.12945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:18:59Z","timestamp":1694240339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,13]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/1754-9485.12945"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12945","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/1754-9485.12997","asserted-by":"object"}]},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,13]]},"assertion":[{"value":"2019-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}