{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:30:26Z","timestamp":1762507826210,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hybrid single photon emission computed tomography (SPECT) with CT (SPECT\/CT) may improve diagnostic accuracy in suspected acute pulmonary embolism, but further research is needed. We evaluated whether the use of attenuation correction and\/or the depiction of lung pathology with hybrid SPECT\/CT could significantly reduce potentially false\u2010positive ventilation\u2013perfusion (VQ) SPECT studies or obviate the need for a ventilation study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two specialists (S1 and S2) reviewed prospectively acquired VQ SPECT\/CT in 165 patients. Studies were reported using standard criteria and compared to VQ SPECT and Q SPECT\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>S1 and S2 recorded positive VQ SPECT in 54 (32.7%) and 42 (25.6%) cases, respectively. Hybrid SPECT\/CT showed non\u2010embolic pathology in 41 (S1) and 46 (S2) patients, but compared to VQ SPECT, neither hybrid SPECT\/CT nor attenuation correction SPECT\/CT had significantly fewer positive studies. Intra\u2010observer agreement with VQ SPECT\/CT was almost perfect (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.91 for S1 and <jats:italic>k<\/jats:italic>\u00a0=\u00a00.95 for S2; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not with Q SPECT\/CT (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.4 for S1 and <jats:italic>k<\/jats:italic>\u00a0=\u00a00.62 for S2; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Inter\u2010observer agreement was moderate for VQ SPECT (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.65) and VQ SPECT\/CT (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, hybrid VQ SPECT\/CT did not reduce the number of potentially false\u2010positive VQ SPECT, nor did the CT obviate the need for a ventilation study. Thus, the routine use of hybrid SPECT\/CT for suspected pulmonary embolism is not justified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12951","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T04:10:11Z","timestamp":1568347811000},"page":"731-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Radionuclide lung scans for suspected acute pulmonary embolism: Single photon emission computed tomography (SPECT) or hybrid SPECT\/CT?"],"prefix":"10.1111","volume":"63","author":[{"given":"Jui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Ultrasound Westmead Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-976X","authenticated-orcid":false,"given":"George","family":"Larcos","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Ultrasound Westmead Hospital Sydney New South Wales Australia"},{"name":"Sydney Medical School University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1390-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.113639"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2010.07.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.124602"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02939.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200211000-00011"},{"key":"e_1_2_6_8_1","first-page":"91P","article-title":"Does the addition of low dose CT improve diagnostic accuracy of V\/Q SPECT scintigraphy? [abstract]","volume":"49","author":"Herald P","year":"2008","journal-title":"J Nucl Med"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.061606"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.157743"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncv130"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.111.101386"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1170-5"},{"key":"e_1_2_6_14_1","unstructured":"National Institutes of Health.A comparison of technegas and xenon\u2010133 planar lung imaging in subjects referred for ventilation scintigraphy. [Cited 14 Jan 2019.] Available from URL:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03054870"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912753"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12681"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166483"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.01980.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2010.07.007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12192"},{"key":"e_1_2_6_21_1","first-page":"842","article-title":"Diagnostic benefit of adding low\u2010dose CT to SPECT V\/Q (letter)","volume":"43","author":"Larcos GS","year":"2013","journal-title":"Intern Med J"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185114533682"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2014.04.003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.03.013"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.09.041"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.12951","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:18:43Z","timestamp":1694240323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/1754-9485.12951"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12951","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"type":"print","value":"1754-9477"},{"type":"electronic","value":"1754-9485"}],"subject":[],"published":{"date-parts":[[2019,9,12]]},"assertion":[{"value":"2019-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}