{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:40:09Z","timestamp":1771483209567,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T00:00:00Z","timestamp":1584230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001254","name":"Ipsen Fund","doi-asserted-by":"publisher","award":["A\u20109B\u201052014\u2010208"],"award-info":[{"award-number":["A\u20109B\u201052014\u2010208"]}],"id":[{"id":"10.13039\/501100001254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neo\u2010adjuvant androgen deprivation therapy prior to radiotherapy (RT) causes shrinkage of the prostate gland, but the changes in volume have never been mapped over time in detail, nor have the associations between volume reduction and testosterone escape or prostate\u2010specific antigen (PSA) kinetics been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty consecutive patients with prostate cancer were treated with 6\u00a0months of triptorelin prior to definitive RT. The volume of the prostate gland was measured at the outset and every 6\u20137\u00a0weeks thereafter using MRI scans. The volumes were calculated using a planimetric method, and inter\u2010rater reliability was checked. Factors associated with a large initial volume and greater reductions in it were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median volume at the outset was 45\u00a0cc, and the median reductions every 6\u00a0weeks thereafter were 23, 18, 9 and 5%. The inter\u2010rater agreement was high (<jats:italic>r<\/jats:italic>\u00a0&gt;\u00a00.9, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). There were no baseline clinical factors associated with a high initial prostate volume, but the initial volume was associated with greater volume reduction. Testosterone escape had no effect on the reduction, and changes in volume were not reflected in PSA response kinetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reductions in volume continue throughout a 6\u2010month course of neo\u2010adjuvant therapy but are greatest during the first 6\u00a0weeks. Although individualisation of the duration or intensity of the hormone treatment warrants further investigation, the role of prostate gland volume reduction remains uncertain. More detailed studies of tumour volume might be possible if the imaging required was acceptable and accessible to patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13017","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T03:58:05Z","timestamp":1584331085000},"page":"287-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is prospective MRI mapping of the changes in the volume of the prostate gland in prostate cancer patients undergoing 6\u00a0months of neo\u2010adjuvant androgen deprivation therapy a step towards a trial to determine those who may benefit from treatment intensification or extended duration?"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-8751","authenticated-orcid":false,"given":"David RH","family":"Christie","sequence":"first","affiliation":[{"name":"GenesisCare Tugun Queensland Australia"},{"name":"Brain\u2010Behaviour Research Group University of New England Armidale New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher F","family":"Sharpley","sequence":"additional","affiliation":[{"name":"Brain\u2010Behaviour Research Group University of New England Armidale New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Mitina","sequence":"additional","affiliation":[{"name":"GenesisCare Tugun Queensland Australia"},{"name":"University of Queensland St Lucia Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamonn","family":"MacAteer","sequence":"additional","affiliation":[{"name":"South Coast Radiology Pindara Hospital Benowa Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E","family":"Jackson","sequence":"additional","affiliation":[{"name":"Icon Cancer Centre Gold Coast University Hospital Southport Queensland Australia"},{"name":"School of Medicine Griffith University Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Lunn","sequence":"additional","affiliation":[{"name":"Icon Cancer Centre Gold Coast University Hospital Southport Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2016.63377"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.03.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.11.025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70348-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.075"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.0419"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-209"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.03.016"},{"key":"e_1_2_6_11_1","article-title":"A prospective study of the effect of testosterone escape on pre\u2010Radiotherapy PSA kinetics in prostate cancer patients undergoing neoadjuvant androgen deprivation therapy","author":"Christie DRH","year":"2019","journal-title":"Curr Urol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6932572"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.1073711"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.04.009"},{"key":"e_1_2_6_15_1","volume-title":"Statistical Power Analysis for the Behavioural Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.3236"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.03.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.01.061"},{"key":"e_1_2_6_19_1","unstructured":"US National Library of Medicine Clinical trial registration.Enzalutamide in Androgen Deprivation Therapy with Radiation Therapy for High Risk Clinically Localised Prostate Cancer (ENZARAD). 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