{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:15:07Z","timestamp":1774451707004,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Due to size and close proximity to skin, the sternum is a complicated target for stereotactic ablative body radiotherapy (SABR). This is a retrospective case series of single\u2010fraction SABR to sternal metastasis in patients with oligometastatic breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between June 2014 and June 2018, ten breast cancer patients received 20\u00a0Gy in 1 fraction to a solitary sternal metastasis. Eligible patients had Eastern Cooperative Oncology Group performance status of 0\u20132, oligometastatic disease (defined as 1\u20135 metastases) and a controlled primary site. Patients were treated with 3\u2010dimensional conformal radiotherapy, each patient case comprising of&gt;\u00a06 coplanar beams and 2\u20136 non\u2010coplanar beams. Local control, pain response and adverse events were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median planned target volumes were 84.75cc (range, 14.4\u2013197.8cc). The median conformity index was 1.29 (range, 1.2\u20131.49). At a median follow\u2010up of 32\u00a0months, nine patients achieved in\u2010field control. Two patients had triple negative disease, one of them developed marginal recurrence, and the other had in\u2010field recurrence. Seven patients had sternal pain prior to SABR, and within 3\u00a0months after SABR treatment, the pain improved (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) or resolved (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). Four patients developed acute grade 1 and 2 skin reactions, and two patients had late grade 1 skin reactions. There were no grade 3 or 4 toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our case series demonstrates safety of SABR with associated disease control and analgesic benefit in selected patients with oligometastatic breast cancer. The marginal recurrence observed in this cohort suggests wider margins could be beneficial to account for microscopic disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13075","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T01:59:55Z","timestamp":1593136795000},"page":"580-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single\u2010fraction stereotactic ablative body radiotherapy for sternal metastases in oligometastatic breast cancer: Technique and single institution experience"],"prefix":"10.1111","volume":"64","author":[{"given":"Michelle P","family":"Li","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Radiation 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