{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:33:14Z","timestamp":1783114394873,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to evaluate the long\u2010term outcome of microwave ablation (MWA) of early\u2010stage non\u2010small cell lung cancer (NSCLC), including response to treatment and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted on consecutive patients who underwent computed tomography\u2010guided MWA of early\u2010stage NSCLC (no evidence of nodal or distant metastasis) from November 2010 to December 2014 at our institution. Data were collected from systematic review of patient charts and imaging. Procedural complications, response to treatment and survival were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>34 early\u2010stage (T1a\u2010T3N0M0) NSCLCs in 30 patients were treated with a total of 41 MWA sessions. There were no intraprocedural or 30\u2010day post\u2010procedural deaths. The most common complication was pneumothorax, encountered in 24 (59%) microwave ablation sessions, six (15%) of which required chest tube insertion. Over a median computed tomography follow\u2010up period of 39\u00a0months (range 3\u201389), 24 (71%) NSCLCs demonstrated local control, while 10 (29%) demonstrated local progression. Nodal\/distant progression was more common than local progression, with 15 of the 30 patients (50%) having nodal or distant metastases at follow\u2010up. Patient survival status was followed up over a median period of 56.5\u00a0months (range 10\u2013107). Median overall survival and 5\u2010year overall survival were 56.5\u00a0months (95% confidence interval, 26\u2010not reached) and 46.7% (95% confidence interval, 31.8\u201368.4), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MWA is safe and effective at achieving local control of early\u2010stage NSCLC and may prolong patient survival. Nodal or distant metastases were the dominant manifestations of disease progression at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13091","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T11:17:23Z","timestamp":1595935043000},"page":"787-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Long\u2010term outcome following microwave ablation of early\u2010stage non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9804-2043","authenticated-orcid":false,"given":"Henry","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Royal Brisbane and Women\u2019s Hospital Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland St Lucia, Brisbane Queensland 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