{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:05:06Z","timestamp":1753887906055,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Suppression of physiological myocardial FDG activity is vital in patients undergoing PET\/CT for assessment of known or suspected cardiac sarcoidosis. This study aims to evaluate the efficacy of physiological myocardial FDG suppression following a protocol change to a 24\u2010h high fat very low carbohydrate (HFVLC) diet and prolonged fast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of patients undergoing FDG PET\/CT for the evaluation of cardiac sarcoidosis was performed. Prior to June\u20102018, patients were prepared with a single very high\u2010fat low carbohydrate meal followed by a 12\u201318 h fast (group 1). After June\u20102018, a protocol change was initiated with patients prepared with a HFVLC diet for 24\u2010h followed by a 12\u201318\u00a0h fast (group 2). Focal myocardial activity was classified as positive, absent activity as negative and diffuse\/focal on diffuse activity as indeterminate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 94 FDG PET\/CT scans were included with 46 scans in group 1 and 48 scans in group 2. Studies were classified as positive, negative or indeterminate in 25 (54%), 7 (15%) and 14 (30%) scans in group 1 and in 13 (27%), 33 (69%) and 2 (4%) scans in group 2, respectively. In scans classified as negative, myocardial FDG activity was less than mediastinal blood pool activity in 5\/7 (71%) scans in group 1 and 33\/33 (100%) scans in group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excellent myocardial FDG suppression can be achieved using a 24\u2010h HFVLC diet and prolonged fast, resulting in a very low indeterminate scan rate in patients with known or suspected cardiac sarcoidosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13121","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T02:44:23Z","timestamp":1603680263000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Excellent suppression of physiological myocardial FDG activity in patients with cardiac sarcoidosis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-5029","authenticated-orcid":false,"given":"Shyam S","family":"Sankaran","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Kyprianou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H","family":"Cherk","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P","family":"Nadebaum","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Beech","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Radiology The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Khor","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Zimmet","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Cardiology The Alfred Hospital Melbourne Victoria Australia"},{"name":"Cardiac Clinical Sciences Institute Epworth Hospital Melbourne Victoria 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W","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET The Alfred Hospital Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University Melbourne Victoria 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