{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:49:19Z","timestamp":1783417759617,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","award":["Early Career Seed Grant (ECSG15024)"],"award-info":[{"award-number":["Early Career Seed Grant (ECSG15024)"]}],"id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The purpose of this study was to describe the nature and impact of dysphagia and dysphonia in patients with limited\u2010stage small\u2010cell lung cancer (SCLC) before and after chemoradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted on patients receiving chemoradiotherapy for limited\u2010stage SCLC. Patients received either 40, 45 or 50\u00a0Gy, commencing the second cycle of chemotherapy. Outcomes included: videofluoroscopy (VFSS) to investigate aspiration, swallowing function and oesophageal motility; oral intake limitations; patient\u2010reported dysphagia; and patient\u2010reported dysphonia. Data were collected before treatment and one, three and six months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients were enrolled. Oropharyngeal swallowing was safe and functional at all times. Three patients exhibited oesophageal motility disorders before treatment, and a further three post\u2010treatment. Oral intake was most compromised one month post\u2010treatment with five patients either tube dependent or eating very limited diets. At all other times patients were eating normal or near\u2010normal diets. Despite normal oropharyngeal swallowing on VFSS, three patients reported moderate or severe dysphagia one month post\u2010treatment. Three additional patients reported moderate or severe difficulties three and six months post\u2010treatment. Patients who reported dysphagia one month post\u2010treatment all received a mean and maximum oesophageal dose of \u226515.7\u00a0Gy and \u226542\u00a0Gy, respectively. Dose\u2013response relationships were not apparent three and six months post\u2010treatment. Voice problems varied, with worst scores reported one month post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified discordance between observed swallowing function and patient\u2010reported problems, which has clinical implications for patient management, and highlights future research needs. Ongoing efforts to reduce mucosal toxicity in patients with lung cancer are essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13290","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T03:42:24Z","timestamp":1626925344000},"page":"786-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functional and patient\u2010reported changes in swallowing and voice after combined chemotherapy and radiotherapy for limited\u2010stage small\u2010cell lung cancer"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-5076","authenticated-orcid":false,"given":"Jacqui","family":"Frowen","sequence":"first","affiliation":[{"name":"Nutrition and Speech Pathology Department Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Victoria 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