{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:01:53Z","timestamp":1790870513235,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012187","name":"St. Vincent's Clinic Foundation","doi-asserted-by":"publisher","award":["$25,000"],"award-info":[{"award-number":["$25,000"]}],"id":[{"id":"10.13039\/100012187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010Fludeoxyglucose PET\u2010CT (FDG) is increasingly used to stage breast cancer. Most breast cancers express the Oestrogen Receptor (ER) and Progesterone Receptor (PR), and this subtype demonstrates lower activity on FDG imaging. Somatostatin receptors (SSTR) offer a potentially improved radiotracer target for ER<jats:sup>+<\/jats:sup>\/PR<jats:sup>+<\/jats:sup> breast cancer. We present the first <jats:italic>in\u00a0vivo<\/jats:italic> clinical study comparing <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE PET\u2010CT (DOTA) to FDG and conventional imaging (bone scan and diagnostic CT), in metastatic ER<jats:sup>+<\/jats:sup>\/PR<jats:sup>+<\/jats:sup> human epidermal growth factor receptor 2 (HER2) negative breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with clinically progressive metastatic ER<jats:sup>+<\/jats:sup>\/PR<jats:sup>+<\/jats:sup> HER2\u2010 breast cancer underwent restaging with DOTA, FDG and conventional imaging. Scans were analysed visually, and semi\u2010quantitatively. Wilcoxon\u2010Rank Scoring was used to assess significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten women (mean age 57\u2009years) underwent imaging. 8\/10 demonstrated disease on both DOTA and FDG. 2\/10 positive on conventional imaging, but DOTA<jats:sup>\u2212<\/jats:sup>\/FDG<jats:sup>\u2212<\/jats:sup>, and had no disease progression at 1\u2010year follow\u2010up. Heterogeneity of uptake was seen between DOTA and FDG with 5 bone lesions DOTA<jats:sup>+<\/jats:sup>\/FDG<jats:sup>\u2212<\/jats:sup> and 1 bone lesion FDG<jats:sup>+<\/jats:sup>\/DOTA<jats:sup>\u2212<\/jats:sup>. Twenty\u2010one visceral lesions were FDG<jats:sup>+<\/jats:sup>\/DOTA<jats:sup>\u2212<\/jats:sup> (2 patients), with 10\/21 identified on conventional imaging. Maximum standard uptake values (SUV max) of DOTA were greater than FDG (10.9 vs. 6.6, <jats:italic>P<\/jats:italic>\u2009=\u2009ns). Four sites were biopsied (3 patients). 3\/4 had high ER\/PR expression (mean DOTA SUV max 9.4) and 1\/4 low ER\/PR expression (DOTA SUV max 3.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Whilst we have not demonstrated DOTA to be superior to FDG in staging of ER<jats:sup>+<\/jats:sup>\/PR<jats:sup>+<\/jats:sup> breast cancers, DOTA may have a role in assessing HR status and treatment decisions; further evaluation of this is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13342","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T05:44:32Z","timestamp":1634881472000},"page":"731-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostic value of <sup>68<\/sup>Ga\u2010DOTATATE PET\u2010CT imaging for staging of ER<sup>+<\/sup>\/PR<sup>+<\/sup> HER2\u2010 breast cancer patients with metastatic disease: Comparison with conventional imaging with bone scan, diagnostic CT and <sup>18<\/sup>F\u2010FDG PET\u2010CT in a prospective pilot trial"],"prefix":"10.1111","volume":"66","author":[{"given":"Andrew","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St Vincent\u2019s Hospital  Sydney New South Wales Australia"},{"name":"St Vincent\u2019s Clinical School UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fullard","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St Vincent\u2019s Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-7922","authenticated-orcid":false,"given":"Gemma","family":"Sheehan\u2010Dare","sequence":"additional","affiliation":[{"name":"Department of Theranostics and Nuclear Medicine St Vincent\u2019s Hospital  Sydney New South Wales 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