{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:02:07Z","timestamp":1765976527850,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This retrospective study aimed to determine the percentage of MRI\u2010detected breast cancers diagnosed using targeted ultrasound and standard 14\u2010gauge (14g) biopsy in the setting of an Australian breast MRI service. This is of clinical relevance because malignancies not identifiable on mammography or by ultrasound may then require more invasive, technically demanding and costly MRI\u2010guided interventional procedures, usually by large\u2010core vacuum\u2010assisted biopsy (VAB) or hook\u2010wire localisation with open surgical biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On review of the 12\u2010year period 2006\u20132018, we identified 67 new breast cancer events in 64 women where the diagnosis was made on the basis of the MRI scan findings either alone (<jats:italic>n<\/jats:italic>\u2009=\u200960) or in combination with a concurrent mammogram (<jats:italic>n<\/jats:italic>\u2009=\u20097), with no recorded clinical abnormality. The percentage in which malignancy was confirmed on histopathology using targeted ultrasound in combination with 14g biopsy was determined versus other biopsy methods, for both invasive cancer and in\u00a0situ disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ultrasound\u2010guided 14g biopsy was successful in establishing the presence of malignancy in 42\/46 (91%) of events with a final diagnosis of invasive cancer, with 2 more proven by MRI\u2010guided interventional procedures (1 VAB and 1 hook\u2010wire) and 1 by open surgical biopsy. In the final case, a 5\u2009mm focus on MRI with no sonographic correlate at the initial presentation was only identified and biopsied by ultrasound at 12\u2010month follow\u2010up.<\/jats:p><jats:p>For events with a final diagnosis of DCIS\/pLCIS (pleomorphic LCIS, <jats:italic>n<\/jats:italic>\u2009=\u20092), US\u2010guided 14g biopsy was successful in 10\/21 (48%), while 4\/7 events with corresponding mammographic microcalcifications were proven by x\u2010ray stereotactic interventions. A further 5 events had MRI\u2010guided interventions (3 VAB and 2 hook\u2010wires) and 1 an open surgical biopsy to confirm malignancy. In the final case (a woman with a 30\u2009\u00d7\u200920\u2009mm focal area of non\u2010mass enhancement with corresponding microcalcifications consistent with DCIS), a pathologic diagnosis was not made until the patient presented 5\u2009years later with invasive disease. There were also 3 instances of upgrades to invasion on final surgical pathology, one from pLCIS to microinvasion and 2 others from DCIS to IDC. Among the DCIS\/pLCIS events, semi\u2010random 14g core biopsy (sampling at the expected location of the MRI abnormality without a specific sonographic correlate) proved to be successful in 3 women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasound\u2010guided 14g core biopsy established a malignant diagnosis in 91% of invasive cancers and in 48% of DCIS\/pLCIS cases. This relatively non\u2010invasive, technically easy to perform and low\u2010cost biopsy procedure can be used immediately when targeted ultrasound shows a correlate for a suspicious MRI scan finding. Careful imaging\u2010pathologic correlation is required after 14g biopsy, and a discordant result will usually prompt recourse to an MRI\u2010guided VAB or hook\u2010wire localisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13352","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T05:19:19Z","timestamp":1637990359000},"page":"738-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["12\u2010year review of MRI\u2010detected breast cancers. How often was a diagnosis of malignancy established using targeted ultrasound and standard 14\u2010gauge core biopsy?"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-0961","authenticated-orcid":false,"given":"Jeremy","family":"Price","sequence":"first","affiliation":[{"name":"Qscan Radiology Clinics  Kingston Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.3322\/canjclin.57.2.75"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1200\/JCO.2009.23.0839"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1038\/bjc.2012.204"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1200\/JCO.2014.56.8626"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1007\/s10549-017-4198-4"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1007\/s10549-020-05642-1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1002\/jmri.26654"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1200\/JCO.2013.52.5386"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1111\/1754-9485.12502"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.2214\/AJR.17.18267"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1016\/j.jacr.2017.11.034"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1001\/jama.2020.0572"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1148\/rg.2019190079"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1200\/JCO.2008.21.5756"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1148\/radiol.14140474"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1148\/rg.335125109"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1111\/tbj.12491"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.2214\/AJR.09.2480"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.2214\/AJR.17.18489"},{"unstructured":"Cancer Australia Australian Government. 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