{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:52:21Z","timestamp":1768888341495,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Stage III melanoma is associated with poor outcomes. We studied the characteristics and outcomes of patients with resected Stage III melanoma before the routine use of adjuvant immunotherapy. Some of these patients received adjuvant nodal radiation with modern radiation techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved data of patients with resected Stage III melanoma treated in Christchurch over 10\u2009years. Overall survival (OS), melanoma\u2010specific survival (MSS), recurrence\u2010free survival (RFS) and nodal recurrence\u2010free rate (NRFR) were determined, and the association of these outcomes with tumour and treatment factors was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 178 patients (110 male and 68 female), of whom 61 received adjuvant radiation. The median age was 66.6\u2009years, and the median follow\u2010up was 2.7\u2009years. First recurrences occurred in 108 (61%) patients. There were 42 (24%) nodal field relapses and 103 (58%) distant relapses. One\u2010half of nodal relapses in patients treated with adjuvant radiation were infield. The 5\u2010year OS, RFS, MSS and NRFR were 46.4%, 26.8%, 53.7% and 69.6%, respectively. Adjuvant radiation was associated with improved RFS and no OS benefit. T4 disease and extranodal spread were associated with poorer OS, while extranodal spread and\u2009&gt;3 involved nodes were associated with worse RFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients treated with adjuvant radiation remain at moderate risk of regional and high risk of distant relapse, despite the use of modern radiation techniques. Adjuvant radiation was associated with improved local control but infield recurrence rates remained a problem. The role of combined adjuvant radiation and immunotherapy in improving these outcomes requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13438","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T10:59:29Z","timestamp":1654081169000},"page":"1003-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adjuvant nodal field radiation in resected Stage <scp>III<\/scp> melanoma: A single\u2010centre retrospective study in Christchurch, New Zealand"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-7163","authenticated-orcid":false,"given":"Tian Weng","family":"Leong","sequence":"first","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service Christchurch Hospital  Christchurch New 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L","family":"James","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service Christchurch Hospital  Christchurch New Zealand"},{"name":"Department of Medicine University of Otago Christchurch  Christchurch New 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