{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:11:40Z","timestamp":1776474700843,"version":"3.51.2"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lower limb ischaemia secondary to occlusion of a lower limb artery is a limb\u2010threatening condition that can be effectively treated by catheter\u2010directed thrombolysis (CDT). The purpose of this study was to examine treatment outcomes of CDT both at the time of treatment and ongoing patency up to 12\u00a0months following treatment. The secondary aim of the study was to investigate the influence of age of occlusion and treatment duration on success and complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective observational study was performed at a single institution over a 10\u2010year period from 2010 to 2019. Data for patient demographics, vessel occlusion factors and treatment information were obtained and analysed. Patency data were investigated using Kaplan\u2013Meier analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 218 limbs in 159 patients were treated during the study period. The aetiology of vessel occlusion was in\u00a0situ thrombosis or occluded bypass graft in 74.5%. Technical success was achieved in 55.5% with CDT alone and 84.4% by using CDT in combination with adjunctive endovascular procedures (angioplasty or stenting). The overall probability of patency was 0.65 at 3\u2009months and 0.44 at 12\u00a0months. The overall rate of major amputation within 30\u2009days of thrombolysis was 8.2%. Thirty\u2010day mortality was 6.3% and was secondary to intracranial haemorrhage in three patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Technical success of CDT was found to be significantly higher when combined with adjunctive endovascular procedures at the time of CDT. Despite an initial moderate technical success, the probability of patency at 12\u00a0months was only 44%. The likelihood of bleeding complications and technical and long\u2010term success remain key considerations when selecting patients for CDT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13496","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T17:37:23Z","timestamp":1670434643000},"page":"421-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Catheter\u2010directed thrombolysis for lower limb ischaemia: A retrospective study of treatment outcomes"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-4742","authenticated-orcid":false,"given":"Sophie","family":"Parker","sequence":"first","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David John","family":"Midgley","sequence":"additional","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Iosua","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Biostatistics Centre University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Galletly","sequence":"additional","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Durran","sequence":"additional","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Lau","sequence":"additional","affiliation":[{"name":"Pacific Radiology Queenstown Queenstown Medical Centre  Queenstown, Otago\/Southland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Reddy","sequence":"additional","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Abcarian","sequence":"additional","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Letts","sequence":"additional","affiliation":[{"name":"Radiology Department Dunedin Public Hospital  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.07.041"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.02.030"},{"key":"e_1_2_7_5_1","first-page":"1105","article-title":"A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators","volume":"388","author":"Ouriel K","year":"1988","journal-title":"N Engl J Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70214-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-948765"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199806)44:2<159::AID-CCD8>3.0.CO;2-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164117695682"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.11.018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.02.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70045-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.03.432"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.07.086"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.13496","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T06:13:11Z","timestamp":1692339191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/1754-9485.13496"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13496","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"2022-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}