{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:46:47Z","timestamp":1776473207594,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To evaluate the role of stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC) patients with inferior vena cava tumour thrombus (IVCTT) who are not suitable for other loco\u2010regional therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an observational retrospective study done between May 2020 and April 2022. The data of 17 patients who underwent SBRT were collected. Patients of Child\u2013Pugh score (CPS) A5\u2010B7 and along with a liver reserve of \u2265700\u2009cc were included. Local control (LC), overall survival (OS) and adverse events including hepatic decompensation were carefully recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the cohort, the tumour thrombus was extended to the right atrium in nine (52.9%) patients, and regional nodal and lung were found in 60% and 31.4% of patients respectively. The median gross tumour volume (GTV) was 745\u2009cc (107\u20131,650\u2009cc). The median SBRT dose prescription was 35\u2009Gy (25\u201345\u2009Gy) in 5\u201310 fractions. At 6\u2009months, LC and OS were 80% and 75% respectively. On multivariate analysis, an ALBI score &gt;\u22122.36 was found to be the predictor for the poor OS. Post\u2010SBRT, a change in CPs by 2 points was observed in one patient (5.9%) which was managed conservatively. Post\u2010radiation, improvement in pain and discomfort was observed in 92.3% and 87% of patients, respectively and bone metastasis related pain was also resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stereotactic body radiotherapy is a safe and feasible option for HCC patients with IVC and right atrium tumour thrombosis. It not only improves the quality of life but also results in good LC and OS with acceptable toxicity. SBRT should be considered in a multidisciplinary fashion for patients presenting with tumour thrombosis extending to IVC and the right atrium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13527","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T11:44:19Z","timestamp":1681127059000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of stereotactic body radiotherapy for inferior vena cava tumour thrombus in hepatocellular carcinoma"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9911-3384","authenticated-orcid":false,"given":"Deepti","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-3362","authenticated-orcid":false,"given":"Deepak","family":"Thaper","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanuman Prasad","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.02.030"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8386"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11962"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5654-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.09.002"},{"key":"e_1_2_8_9_1","unstructured":"Cancer Institute N.Common Terminology Criteria for Adverse Events (CTCAE) v5.0.2017. 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