{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:49:32Z","timestamp":1790315372302,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020021","name":"Avant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We evaluated real\u2010world data on the patterns and outcomes of radiotherapy (RT) for brain metastases (BM) in a population\u2010based cohort of patients with lung cancer (LC) in Victoria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Victorian Radiotherapy Minimum Data set (VRMDS) and the Victorian Cancer Registry (VCR) were linked to identify patients with LC who underwent RT for BM between 2013 and 2016. We determined: (i) proportion of patients treated with stereotactic radiosurgery (SRS); (ii) overall survival (OS); and (iii) 30\u2010day mortality (30M) following RT for BM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1001 patients included in the study, 193 (19%) had SRS. There was no significant increase in SRS use over time \u2013 from 18% in 2013 to 21% in 2016 (<jats:italic>P<\/jats:italic>\u2010trend\u2009=\u20090.8). In multivariate analyses, increased age (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) and treatment in regional centres (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were independently associated with lower likelihood of SRS treatment. The median OS following RT for BM was 3.6\u2009months. Patients who had SRS had better OS than those who did not have SRS (median OS 8.9\u2009months vs. 3\u2009months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). SRS use, age, sex and year of treatment were independently associated with OS in multivariate analyses. A total of 184 (18%) patients died within 30\u2009days of RT for BM, and the proportion was higher in older (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and male patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One\u2010in\u2010five LC patients who received RT for BM had SRS. The improved OS with SRS is likely confounded by patient selection. It is important to reduce 30M by better selecting patients who may not benefit from RT for BM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13545","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T21:49:37Z","timestamp":1686088177000},"page":"546-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010world data on patterns and outcomes of radiation therapy for brain metastases in a population\u2010based cohort of lung cancer patients in Victoria"],"prefix":"10.1111","volume":"67","author":[{"given":"Therese Min Jung","family":"Kang","sequence":"first","affiliation":[{"name":"Alfred Health Radiation Oncology  Melbourne Victoria Australia"},{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Victoria 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