{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:09:38Z","timestamp":1780445378259,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:00:00Z","timestamp":1692403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Renal angiomyolipomas (AMLs) are vascular tumours that while histologically benign, carry a risk of rupture and potentially life\u2010threatening haemorrhage. Selective arterial embolisation (SAE) has been demonstrated as effective treatment; however, given most tumours are asymptomatic, the challenge facing the radiologist is selection of which AML should undergo treatment. This study considers presence and size of intratumoural aneurysm, to advance the readers treatment decision\u2010making beyond historical size criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort analysis of all SAE\u2010treated AML at a quaternary\u2010level institution in the last 10\u2009years was completed independently by two radiologists. Computerised tomography (CT) and angiographic imaging were reviewed to evaluate tumour size, presence of intratumoural aneurysm and aneurysm size. Univariant and multivariant statistical analyses were used to identify predictors of spontaneous rupture and haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven renal AML underwent SAE. Five tumours had presented with haemorrhage. Twenty\u2010two were asymptomatic or without CT\/angiographic detectable haemorrhage. There was no statistically significant size difference between ruptured (mean 7.8\u2009cm, range 6.1\u201312.0\u2009cm) and unruptured AML (7.5\u2009cm, 3.3\u201321.7\u2009cm) in the study population. Eighty percent of ruptured AML and 27% of unruptured AML contained at least one intratumoural aneurysm (<jats:italic>P<\/jats:italic>\u2010value\u2009&lt;\u20090.05). Mean aneurysm size in ruptured AMLs was 5.4\u2009mm, versus 4.6\u2009mm among unruptured AML (<jats:italic>P<\/jats:italic>\u2010value\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of intratumoural aneurysm is a useful predictor for AMLs that are at risk of spontaneous rupture and haemorrhage. Intratumoural aneurysm should therefore be considered when selecting patients to undergo SAE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13547","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T12:18:31Z","timestamp":1692447511000},"page":"619-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Renal angiomyolipoma: Beyond size criteria for predicting rupture"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-1185","authenticated-orcid":false,"given":"Simon","family":"McQueen","sequence":"first","affiliation":[{"name":"Department of Radiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Combes","sequence":"additional","affiliation":[{"name":"Department of Urology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,19]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Robbins & Cotran Pathological Basis of Disease","author":"Kumar V.","year":"2020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42155-020-00179-2"},{"key":"e_1_2_7_4_1","unstructured":"GettleLM HellerMT.Renal Angiomyolipoma.statdx. [Online] [Cited 4 Dec 2022.] Available from URL:https:\/\/app.statdx.com\/document\/renal\u2010angiomyolipoma\/c37be4ca\u2010605f\u2010438e\u2010acc9\u2010fd75d98bc39c?term=Tuberous%20Sclerosis%20Complex&searchType=documents&category=Genitourinary."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00838.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019180043"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2019.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)46013-7"},{"key":"e_1_2_7_9_1","first-page":"20","article-title":"A scoring system based on clinical features for the prediction of sporadic renal angiomyolipoma rupture and hemorrhage","volume":"99","author":"Xu X\u2010F","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.15586\/jkcvhl.v9i1.177"},{"key":"e_1_2_7_11_1","unstructured":"DawsonC.Guidelines for the active surveillance of angiomyolipoma. Urology Clinical Governance Lead (2017). [Online].2017. [Cited 4 Dec 2022.]Pchurology.co.uk."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2251011477"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61767-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)58367-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.04.081"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.04.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2017.10.002"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:48:09Z","timestamp":1696409289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,19]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/1754-9485.13547"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13547","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,19]]},"assertion":[{"value":"2022-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}