{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:01Z","timestamp":1747182541808,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T00:00:00Z","timestamp":1689465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Guidelines for clinical target volume (CTV) to planning target volume (PTV) margins in post\u2010prostatectomy radiation therapy (PPRT) are varied and often not clearly defined. Assessment of appropriateness of margins is commonly measured on prevalence of geographic miss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cone\u2010beam CT (CBCT) images (<jats:italic>n<\/jats:italic>\u2009=\u200992) for 10 PPRT patients were incorporated to provide on\u2010treatment information on the appropriateness of six different CTV expansion margins in terms of geographic miss and change in dose\u2010volume statistics for CTV, rectum and bladder. Uniform margins included 10\u2009mm, 5\u2009mm, 10\u2009mm\u2009+\u20095\u2009mm posteriorly and 5\u2009mm\u2009+\u20093\u2009mm posteriorly. In addition, two anisotropic margins were evaluated by separating the superior and inferior portions of the CTV before expansion. Treatment plans were created for each PTV retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of geographic miss was the smallest for the large uniform expansions but resulted in the highest organ\u2010at\u2010risk (OAR) doses. Geographic miss in the smaller uniform and anisotropic PTVs was more prevalent but commonly to a small volume\u2009&lt;\u20091% of CTV. When averaged over all CBCT fractions, V95% dose for all CTV margins remained &gt; 99%. The anisotropic expansions generated smaller irradiated target volumes and consequently saw up to 7.3% reduction in bladder dose when compared with similar uniform expansion margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Supplementing the incidence of geographic miss with dosimetric information on target coverage and OAR doses provides more informed assessment of the appropriateness of different CTV expansion margins. Our study extends the evaluation of anisotropic margins for PPRT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13563","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T18:15:11Z","timestamp":1689531311000},"page":"796-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the geometric and dosimetric impact of applying anisotropic CTV to PTV margins in image\u2010guided post\u2010prostatectomy radiation therapy"],"prefix":"10.1111","volume":"67","author":[{"given":"Emma","family":"Grierson","sequence":"first","affiliation":[{"name":"Illawarra Cancer Care Centre  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-2001","authenticated-orcid":false,"given":"Dean","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Illawarra Cancer Care Centre  Wollongong New South Wales Australia"},{"name":"Centre for Medical Radiation Physics University of Wollongong  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-3587","authenticated-orcid":false,"given":"Lauren","family":"Causer","sequence":"additional","affiliation":[{"name":"Illawarra Cancer Care Centre  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6521-0805","authenticated-orcid":false,"given":"Jeremiah","family":"de Leon","sequence":"additional","affiliation":[{"name":"Illawarra Cancer Care Centre  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61253-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.03.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.11.032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31952-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.05.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.07.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.12.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.042"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12089"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-016-1077-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0467-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-014-0631-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.05.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1460396921000327"},{"key":"e_1_2_7_19_1","unstructured":"https:\/\/www.eviq.org.au\/. 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