{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:41:21Z","timestamp":1781134881384,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:00:00Z","timestamp":1698537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Malignant pleural mesothelioma is difficult to prognosticate. F18\u2010Fluorodeoxyglucose positron emission tomography (FDG PET) shows promise for response assessment but is confounded by talc pleurodesis. F18\u2010Fluorothymidine (FLT) PET is an alternative tracer specific for proliferation. We compared the prognostic value of FDG and FLT PET and determined the influence of talc pleurodesis on these parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 29 prospectively recruited patients had FLT PET, FDG PET and CT\u2010scans performed prior to and post one chemotherapy cycle; 10 had prior talc pleurodesis. Patients were followed for overall survival. CT response was assessed using mRECIST. Radiomic features were extracted using the MiM software platform. Changes in maximum SUV (SUVmax), mean SUV (SUVmean), FDG total lesion glycolysis (TLG), FLT total lesion proliferation (TLP) and metabolic tumour volume (MTV) after one chemotherapy cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cox univariate analysis demonstrated FDG PET radiomics were confounded by talc pleurodesis, and that percentage change in FLT MTV was predictive of overall survival. Cox multivariate analysis showed a 10% increase in FLT tumour volume corresponded with 9.5% worsened odds for overall survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.028, HR\u2009=\u20091.095, 95% CI [1.010, 1.187]). No other variables were significant on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first prospective study showing the statistical significance of FLT PET tumour volumes for measuring mesothelioma treatment response. FLT may be better than FDG for monitoring mesothelioma treatment response, which could help optimise mesothelioma treatment regimes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13592","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:10:06Z","timestamp":1698603006000},"page":"57-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The prognostic value of F18 Fluorothymidine positron emission tomography for assessing the response of malignant pleural mesothelioma to chemotherapy \u2013 A prospective cohort study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-7731","authenticated-orcid":false,"given":"Isaac J","family":"May","sequence":"first","affiliation":[{"name":"Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K","family":"Nowak","sequence":"additional","affiliation":[{"name":"Medical Oncology, Sir Charles Gairdner Hospital  Nedlands Western Australia Australia"},{"name":"National Centre for Asbestos Related Diseases (NCARD)  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn J","family":"Francis","sequence":"additional","affiliation":[{"name":"Department Nuclear Medicine, Sir Charles Gairdner Hospital  Nedlands Western Australia Australia"},{"name":"Faculty of Medicine, School of Medicine and Pharmacology The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A","family":"Ebert","sequence":"additional","affiliation":[{"name":"Radiation Oncology Cancer, Imaging &amp; Clinical Services, Sir Charles Gairdner Hospital  Nedlands Western Australia Australia"},{"name":"Department of Physics, School of Physics, Mathematics and Computing The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvinder S","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Curtin Health Innovation Research Institute, Faculty of Health Sciences, B305 Curtin University  Bentley Western Australia Australia"},{"name":"Duke\u2010NUS Medical School National University of Singapore  Singapore City Singapore"},{"name":"Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia  Penang Pulau Pinang Malaysia"},{"name":"Singapore University of Social Sciences  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.12.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146110"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.05.23"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-014-0063-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.188029"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-2-56"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2313"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.042333"},{"key":"e_1_2_12_10_1","first-page":"1426","article-title":"Imaging proliferation in lung tumors with PET: 18F\u2010FLT versus 18F\u2010FDG","volume":"44","author":"Buck AK","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.393"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-005-0029-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4008"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0446-x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.6.2356"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:46:32Z","timestamp":1707713192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,29]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/1754-9485.13592"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13592","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,29]]},"assertion":[{"value":"2022-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}