{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T03:10:01Z","timestamp":1710731401362},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008719","name":"Movember Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To evaluate patient reported quality of life outcomes (QoL) following low\u2010dose\u2010rate brachytherapy (LDR\u2010BT) and high\u2010dose\u2010rate brachytherapy (HDR\u2010BT) monotherapy for prostate cancer at a population\u2010based setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised men with low\u2010intermediate risk prostate cancer in the Prostate Cancer Outcomes Registry Victoria (PCOR\u2010Vic), who were treated with LDR\u2010BT or HDR\u2010BT monotherapy between 2015 and 2020 and completed the Expanded Prostate Cancer Index Composite (EPIC\u201026) questionnaire 12\u2010month post\u2010treatment. Men who had ADT were excluded (<jats:italic>n<\/jats:italic>\u2009=\u200912). Differences in substantial symptoms (i.e. \u2018moderate\u2019 or \u2018big\u2019 problem on a 5\u2010point Likert scale) between LDR\u2010BT and HDR\u2010BT arms were evaluated using Pearson's chi\u2010squared test. Multivariable linear regressions were used to estimate differences in EPIC\u201026 urinary, bowel and sexual functional domain scores between LDR\u2010BT and HDR\u2010BT arms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 198 men were included in this study, of which 167 (84%) had LDR\u2010BT and 31 (16%) had HDR\u2010BT. 9 (4.6%), 10 (5.1%) and 56 (28%) reported substantial symptoms for overall urinary, bowel and sexual function at 12\u2010month post\u2010treatment, with no significant difference between LDR\u2010BT and HDR\u2010BT arms. The adjusted mean differences in urinary incontinence, urinary obstructive, bowel and sexual function domain scores between LDR\u2010BT and HDT\u2010BT were: \u22123.53 (\u22128.21 to 1.14), \u22121.27 (\u22126.88 to 4.35), \u22120.01 (\u22125.63 to 5.63) and \u22128.68 (\u221221.44 to 4.07) respectively \u2013 these were not statistically significant and did not meet the minimal clinically important difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first Australian population\u2010based study comparing QoL in men who had LDR\u2010BT and HDR\u2010BT, with no statistically or clinically significant differences in QoL observed at 12\u2010month post\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13596","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T02:05:32Z","timestamp":1697162732000},"page":"789-795","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Population\u2010based patient\u2010reported quality of life outcomes following low\u2010dose\u2010rate versus high\u2010dose\u2010rate brachytherapy monotherapy for low\u2010intermediate risk prostate cancer"],"prefix":"10.1111","volume":"67","author":[{"given":"Wee Loon","family":"Ong","sequence":"first","affiliation":[{"name":"Alfred Health Radiation Oncology, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre University 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