{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:07:56Z","timestamp":1768266476144,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The most common form of endometrial cancer is Type 1 endometrioid adenocarcinoma. Depth of myometrial invasion is the most important prognostic factor correlating with overall patient survival. The objective was to investigate how accurate magnetic resonance imaging (MRI) is in predicting the depth of myometrial invasion in preoperative assessment, and the influence of leiomyoma and\/or adenomyosis, or microcystic, elongated and fragmented (MELF) pattern of invasion on MRI diagnostic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective audit of 235 endometrial cancer patients from the regional Gynaecology Oncology multidisciplinary meeting at Auckland City Hospital, between January 2020 and January 2021. Radiologist assigned stage was compared to histopathology. Presence of leiomyoma, adenomyosis and\u00a0MELF pattern evaluated followed by analysis under a Biostatistician's supervision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall MRI diagnostic accuracy for depth of myometrial invasion was 86%. For deep myometrial invasion, MRI had a sensitivity of 72% and specificity 91%. Out of the misreported 32\/235 cases, 16 demonstrated fibroids and\/or adenomyosis leading to a sensitivity of 57% and specificity 93% for deep invasion, compared with 94% and 74% respectively in the population without, demonstrating statistical significance. Thirty seven cases with MELF pattern of invasion showed a sensitivity of 81% and specificity 80% for deep invasion, compared with 63% and 92% respectively in the group without, demonstrating no statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MRI assessment of the depth of myometrial invasion in endometrial cancer has high accuracy. In the presence of background uterine fibroids\/adenomyosis, pre\u2010operative MRI accuracy of evaluating deep invasion shows a statistically significant reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13622","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T18:03:42Z","timestamp":1708452222000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Accuracy of MRI in predicting deep myometrial invasion in endometrial cancer and the influence of leiomyoma, adenomyosis and the microcystic elongated and fragmented tumour pattern"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1653-6359","authenticated-orcid":false,"given":"Anuja","family":"Liyanage","sequence":"first","affiliation":[{"name":"Department of Radiology Te Whatu Ora \u2013 Health New Zealand  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Cardoza","sequence":"additional","affiliation":[{"name":"Te Whatu Ora Counties Manukau Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darshna","family":"Kasabia","sequence":"additional","affiliation":[{"name":"Te Whatu Ora Counties Manukau Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Moore","sequence":"additional","affiliation":[{"name":"Te Whatu Ora Auckland City Hospital, Auckland Radiology Group  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"CapesG.Endometrial cancer survivorship: improving long\u2010term outcomes. n.d. [Cited 20 Jan 2023.] Available from URL:https:\/\/www.waitematadhb.govt.nz\/assets\/Documents\/research\/Symposium\/21\u2010endometrial\u2010cancer\u2010poster.pdf."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2022.33.e22"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133275"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2011.10.019"},{"key":"e_1_2_8_6_1","first-page":"20","article-title":"Diagnostic accuracy of preoperative magnetic resonance imaging in assessing prognostic pathological parameters in endometrial carcinoma","volume":"2","author":"Yasmeen T","year":"2020","journal-title":"Liaquat National Tumour Board J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5505\/ejm.2021.54770"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3671-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-020-01227-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01059.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2019-0153"},{"key":"e_1_2_8_12_1","unstructured":"MishraH.Endometrial carcinoma (staging): radiology reference article. Radiopaedia Blog RSS.2022. [Cited 21 Jan 2023.] Available from URL:https:\/\/radiopaedia.org\/articles\/endometrial\u2010carcinoma\u2010staging\u20102?lang=gb."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4825(00)00006-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12081268"},{"key":"e_1_2_8_15_1","first-page":"19501","article-title":"Magnetic resonance imaging for detection of depth of myometrial invasion and cervical invasion in patients with endometrial carcinoma","volume":"8","author":"Yin X","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-013-9699-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2013.04.010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182571490"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/181963"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.09.018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5465-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031369"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.321115045"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01166.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12048"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000245444.14015.00"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4293\/JSLS.2020.00011"},{"key":"e_1_2_8_28_1","first-page":"211","article-title":"Diagnostic problems on frozen section examination of myometrial invasion in patients with endometrial carcinoma with special emphasis on the pitfalls of deep adenomyosis with carcinomatous involvement","volume":"25","author":"Kir G","year":"2004","journal-title":"Euro J Gynecol Oncol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03356-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/0100-3984.2018.0054"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:56:15Z","timestamp":1714064175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/1754-9485.13622"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13622","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}