{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:41:31Z","timestamp":1765806091365,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971644"],"award-info":[{"award-number":["81971644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The purpose of the study was to determine the usefulness of Ga\u201068 DOTATATE PET\/MR in the identification of tumours in individuals with multiple endocrine neoplasia type 1 (MEN1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective investigation, five individuals who had tested positive for a hereditary MEN1 variant underwent Ga\u201068 DOTATATE PET\/MR between May 2020 and January 2023. Several types of tumours associated with MEN1 were studied. MEN1\u2010related tumours included pituitary, parathyroid, gastroenteropancreatic, and adrenal. The rates of lesion identification between MRI, Ga\u201068 DOTATATE PET, and Ga\u201068 DOTATATE PET\/MRI were examined. The maximum and mean standard uptake values (SUVmax and SUVmean) were evaluated in carefully delineated volumes of interest (VOI) for the relevant tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 24 primary lesions, 14 were identified by Ga\u201068 DOTATATE PET, 18 by MRI, and 20 by Ga\u201068 DOTATATE PET\/MRI. Two pituitary tumours were detected by all three techniques. All parathyroid tumours that were not detected by Ga\u201068 DOTATATE PET and MRI were found by Tc\u201099m MIBI SPECT\/CT or\/and EUS. Ga\u201068 DOTATATE PET\/MR detected more gastroenteropancreatic lesions. All adrenal tumours not identified by Ga\u201068 DOTATATE PET were found by MRI or CT. The median SUVmax for lesions identified on Ga\u201068 DOTATATE PET\/MRI was 18.4 (range, 3.8\u201085.2), and the median SUVmean was 12.0 (range, 2.3\u201049.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of Ga\u201068 DOTATATE PET and MRI demonstrated a higher detection rate and may be more useful in the work\u2010up of MEN1 providing a panoramic view of MEN1\u2010related lesions. To increase the identification of MEN1\u2010associated neuroendocrine lesions in the parathyroid gland, approaches other than Ga\u201068 DOTATATE PET\/MRI should be used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13641","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T13:48:11Z","timestamp":1712065691000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The lesion detection rate of Ga\u201068 <scp>DOTATATE PET<\/scp>\/<scp>MR<\/scp> in multiple endocrine neoplasia type 1"],"prefix":"10.1111","volume":"68","author":[{"given":"Jing","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-6232","authenticated-orcid":false,"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3690"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-20-0020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.04.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0634-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab891"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0702-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-3907-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2309-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.233940"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0125"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000825"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"172s","article-title":"(68)Ga\u2010labeled peptides in tumor imaging","volume":"46","author":"Maecke HR","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122501"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i26.3008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0778"},{"key":"e_1_2_8_18_1","first-page":"44","article-title":"Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates","volume":"11","author":"Marquis H","year":"2023","journal-title":"Asia Ocean J Nucl Med Biol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191916"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000457"},{"issue":"1","key":"e_1_2_8_21_1","first-page":"1143","article-title":"Increased pituitary uptake in time of flight Ga\u201068 DOTATATE imaging. How much is too much and does it matter?","volume":"60","author":"Fleming S","year":"2019","journal-title":"J Nucl Med"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0231"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.802453"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0679"},{"key":"e_1_2_8_25_1","first-page":"2","article-title":"Normal variants, pitfalls and artifacts in Ga\u201068 DOTATATE PET\/CT imaging","volume":"2","author":"Malan N","year":"2022","journal-title":"Front Nucl Med"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2217\/ije.15.29"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-17-0006"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:55:48Z","timestamp":1714064148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/1754-9485.13641"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13641","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"type":"print","value":"1754-9477"},{"type":"electronic","value":"1754-9485"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}