{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:50:22Z","timestamp":1780368622933,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In the current American Joint Committee on Cancer staging system, patients with pelvic nodal metastases are considered stage IV prostate cancer. This study aims to investigate whether men with prostate\u2010specific membrane antigen positron emission tomography (PSMA PET)\u2010detected pelvic node\u2010positive prostate cancer at diagnosis have a better outcome compared to men with node\u2010positive disease identified on conventional imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study comparing the outcomes of men with node\u2010positive prostate cancer and disease confined to the pelvis, staged with conventional versus PSMA PET imaging. Men had to be treated definitively with a combination of androgen deprivation therapy and radiation treatment to the prostate and pelvic lymph nodes. Kaplan\u2013Meier and Cox regression analysis was used to compare biochemical failure\u2010free survival (BFFS) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010six men with nodal metastases confined to the pelvis were identified. Fifty\u2010one were detected with PSMA PET while 25 were staged with conventional imaging. PSMA PET staged patients had a lower proportion of Gleason 8\u201310 disease (78% vs. 96%) as well as a lower median prostate\u2010specific antigen (11\u2009ng\/mL vs. 26\u2009ng\/mL). BFFS at 4\u2009years was 72% with PSMA PET\u2010detected node\u2010positive disease vs. 38% with conventionally detected node\u2010positive disease. Four\u2010year OS was 93% with PSMA PET staged patients vs. 76% with conventionally staged patients. On multivariate analysis, the PSMA PET staged group was associated with improved BFFS (Adjusted HR\u2009=\u20093.00, 95% CI 1.43, 6.29, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) and OS (Adjusted HR\u2009=\u20095.81, 95% CI 1.43, 23.7, <jats:italic>P<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Men with PSMA PET\u2010detected node\u2010positive prostate cancer confined to the pelvis have significantly better biochemical control and survival compared to those with node\u2010positive pelvic disease identified through conventional staging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13655","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T09:30:50Z","timestamp":1713173450000},"page":"721-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic impact of prostate\u2010specific membrane antigen positron emission tomography (<scp>PSMA PET)<\/scp> staging for clinically node\u2010positive prostate cancer"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4580-3563","authenticated-orcid":false,"given":"Boon Yang Jerome","family":"Leow","sequence":"first","affiliation":[{"name":"Central Coast Cancer Centre Gosford Hospital  Gosford New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eade","sequence":"additional","affiliation":[{"name":"Central Coast Cancer Centre Gosford Hospital  Gosford New South Wales Australia"},{"name":"Northern Sydney Cancer Centre, Radiation Oncology Unit Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4193-9682","authenticated-orcid":false,"given":"George","family":"Hruby","sequence":"additional","affiliation":[{"name":"Northern Sydney Cancer Centre, Radiation Oncology Unit Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"Lieng","sequence":"additional","affiliation":[{"name":"Central Coast Cancer Centre Gosford Hospital  Gosford New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Brown","sequence":"additional","affiliation":[{"name":"Northern Sydney Cancer Centre, Radiation Oncology Unit Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"National Health and Medical Research Council, Clinical Trials Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-504X","authenticated-orcid":false,"given":"Andrew","family":"Kneebone","sequence":"additional","affiliation":[{"name":"Central Coast Cancer Centre Gosford Hospital  Gosford New South Wales Australia"},{"name":"Northern Sydney Cancer Centre, Radiation Oncology Unit Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30314-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.197160"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13540"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12872"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.05.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01168-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2012.11.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.01.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv119"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.4350"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.08.034"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2019.03.015"},{"key":"e_1_2_7_16_1","unstructured":"KneeboneA.Optimal Prostate Study. [2 Oct 2018.] Available from URL:https:\/\/classic.clinicaltrials.gov\/show\/NCT03386045."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.07.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0197-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09283-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2022.09.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.039"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02437-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.18383\/j.tom.2018.00021"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T07:58:54Z","timestamp":1728460734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/1754-9485.13655"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13655","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]},"assertion":[{"value":"2023-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}