{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:38:31Z","timestamp":1785368311679,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["6242\u2010P6\/RGCB\/PMD\/DBT\/RMPA\/2015"],"award-info":[{"award-number":["6242\u2010P6\/RGCB\/PMD\/DBT\/RMPA\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Locally advanced carcinoma cervix (LACC) is a heterogeneous disease with variable combinations of primary tumour extensions with or without nodal involvement. Metabolic information from 18 fluro\u2010deoxyglucose positron emission tomography combined with contrast\u2010enhanced computerized tomography (FDG PET\u2010CT) may potentially augment treatment decision\u2010making for LACC. This study ascertained FDG\u2010PET CT influence on chemoradiation therapy (CTRT) decisions in LACC. We report oncologic and patient\u2010reported outcome measures (PROMs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FDG PET\u2010CT scans were reviewed independently by two nuclear medicine specialists and two radiation oncologists. Pelvic CTRT plan digressions were documented and therapy was adapted accordingly. Pelvis radiation (50\u2009Gy\/25#\/5\u2009weeks) using tomotherapy with weekly cisplatin was used in node\u2010negative disease. Dose\u2010escalated simultaneous integrated boost (SIB) 60\u2009Gy\/25#\/5\u2009weeks was delivered to involved pelvic nodes. All received brachytherapy. Post\u2010treatment PET\u2010CT scans were at 6\u2009months. Functional assessment of cancer therapy scores were calculated at baseline, treatment completion, 3\u2009months, 1\u2009year and 3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between November 2015 and January 2018, 85 patients were screened, and 77 consented. Extrapelvic disease was seen in 12 (16%) patients (9 para\u2010aortic nodes, 2 distant metastases and 1 synchronous carcinoma breast); 60 patients were included in the final analysis. Decision changes were seen in 10\/77 (13%) screened, 8\/60 (13%) included and 32 (53.3%) received SIB. Post\u2010treatment, 27 (45%) had grade 2 GI\/GU\/GYN toxicity, one (2%) had grade 3 GI and five (8.3%) had grade 3 neutropenia. At median follow\u2010up of 54.2\u2009months (95% CI 52.8\u201358.3), 5\u2010year local failure, pelvic nodal and para\u2010aortic nodal\u2010free survival were 86.8% (95% CI 78.0\u201396.6), 85.2% (95% CI 76.1\u201395.3) and 85.2% (95% CI 76.2\u201395.4). Functional assessment of cancer therapy trial outcome index (FACT TOI) improved by 10.43 at 3\u2009months with no further decline. Grade 3 toxicity was noted for abdominal pain in one (1.7%), cystitis in four (6.7%) and lymphoedema in one (1.7%) at 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PET\u2010CT resulted in major decision changes in 13%. PET\u2010adapted CTRT was associated with acceptable toxicity, encouraging long\u2010term survival and improvement in PROMS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13667","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:41:11Z","timestamp":1718365271000},"page":"624-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["18<scp>F<\/scp>\u2010fluorodeoxyglucose <scp>PET\u2010CT<\/scp>\u2010guided pelvic chemoradiation therapy using helical tomotherapy for locally advanced carcinoma cervix without para\u2010aortic nodal disease: Clinical and patient\u2010reported outcomes from a prospective phase 2 study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-255X","authenticated-orcid":false,"given":"Rimpa Basu","family":"Achari","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santam","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumendranath","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurupa","family":"Mahata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanishka","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Mallick","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-3203","authenticated-orcid":false,"given":"Jaydip","family":"Bhaumik","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncosurgery Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basumita","family":"Chakraborti","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncosurgery Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncosurgery Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saugata","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Radiology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Radiology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjoy","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Arunsingh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapesh","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Medical Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"The International Agency for Research on Cancer (IARC). 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