{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:20Z","timestamp":1747182560313,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020840","name":"Australian Research Data Commons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020840","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite the availability of radiotherapy treatment protocols for\u00a0lung cancer, considerable treatment variation occurs in clinical practice. This study assessed compliance with a radiotherapy protocol for the treatment of patients with stages I\u2013III non\u2010small\u2010cell lung cancer (NSCLC) in routine clinical practice and to identify factors that were associated with compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Cancer Institute New South Wales eviQ treatment protocol for external beam radiotherapy of stages I\u2013III NSCLC was taken as the reference to measure compliance. All inoperable patients with stages I\u2013III NSCLC and documented ECOG performance status treated with radiotherapy between 2007 and 2019 at two radiotherapy facilities were available for analysis. Protocol compliance rates were calculated. Univariate and multivariate logistic regression models with 23 input factors were used to determine factors significantly associated with compliance. Survival analysis was conducted for both compliant and non\u2010compliant treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 656 patients met the inclusion criteria. Protocol compliance was 16%. Alternative dose\/fractionation was responsible for 49% of non\u2010compliant treatments with 30% receiving an alternative curative fractionation. Five of 23 factors (age at the start of radiotherapy, stage group, ECOG performance status, tumour location and alcoholism history) showed significant associations with protocol compliance on multivariate analysis. There was no significant difference in median survival between patients receiving protocol compliant treatment (15.1\u2009months) and non\u2010compliant treatment (15.6\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adherence to the eviQ curative radiotherapy protocol for stages I\u2013III NSCLC was low. Alternative dose\/fractionation schemes were the main reason for non\u2010compliance. Protocol compliance was not associated with outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13727","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:24:14Z","timestamp":1722331454000},"page":"729-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy protocol compliance in routine clinical practice for patients with stages I\u2013III non\u2010small\u2010cell lung cancer"],"prefix":"10.1111","volume":"68","author":[{"given":"Xiaoshui","family":"Huang","sequence":"first","affiliation":[{"name":"Image X Institute University of Sydney  Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6169-6721","authenticated-orcid":false,"given":"Matthew","family":"Field","sequence":"additional","affiliation":[{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"},{"name":"South Western Clinical Campus, School of Medicine University of NSW  Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres South Western Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-6219","authenticated-orcid":false,"given":"Shalini","family":"Vinod","sequence":"additional","affiliation":[{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"},{"name":"South Western Clinical Campus, School of Medicine University of NSW  Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres South Western Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ball","sequence":"additional","affiliation":[{"name":"Image X Institute University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-2599","authenticated-orcid":false,"given":"Vikneswary","family":"Batumalai","sequence":"additional","affiliation":[{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"},{"name":"South Western Clinical Campus, School of Medicine University of NSW  Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres South Western Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-6507","authenticated-orcid":false,"given":"Paul","family":"Keall","sequence":"additional","affiliation":[{"name":"Image X Institute University of Sydney  Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-2165","authenticated-orcid":false,"given":"Lois","family":"Holloway","sequence":"additional","affiliation":[{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"},{"name":"South Western Clinical Campus, School of Medicine University of NSW  Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres South Western Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Cancer Council Australia.Clinical Practice Guidelines.2024[cited 25 Jun 2024]. Available from URL:https:\/\/www.cancer.org.au\/clinical-guidelines."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2016.04.045"},{"key":"e_1_2_7_4_1","unstructured":"Cancer Institute NSW.eviQ Radiation Oncology.2024[cited 25 Jun 2024]. 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