{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T05:05:44Z","timestamp":1736139944315,"version":"3.32.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study compared the predictive ability of radiation\u2010induced cataract between maximum point dose of the lens (Lens Dmax) \u22657\u2009Gy, mean lens dose (Lens Dmean) \u22657\u2009Gy, Lens Dmax \u226510\u2009Gy, and Lens Dmean \u226510\u2009Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients aged 3\u201318\u2009years received cranial irradiation or radiation therapy at head and neck area between January 2010 and December 2019 at our institute were included. Patients without baseline and\/or follow\u2010up eye examination were excluded. Receiver operating characteristic (ROC) curves identified potential predictors and Cox regression analysed correlations between potential factors and cataract occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three patients (122 eyes) were analysed. Cataracts were detected in 14 eyes (11.5%). Median follow\u2010up time was 4\u2009years (range 0.5\u201310\u2009years), with cataract developing in a median of 2.5\u2009years (range 0.3\u20137\u2009years). Three patients (21.4%) developed grade\u2009\u22653 cataract. Lens Dmean \u226510\u2009Gy was associated with cataract formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lens Dmean \u226510\u2009Gy showed the highest ability for predicting radiation\u2010induced cataract in paediatric patients. Net reclassification improvement (NRI) suggested that changing lens dose constraint from Dmax &lt;7\u2009Gy to Dmean &lt;10\u2009Gy would miss 7% of cataract cases but avoid 28% of unnecessary restrictions. Adopting a mean lens dose &lt;10\u2009Gy was suggested as a constraint for lens dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13748","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T19:03:24Z","timestamp":1724958204000},"page":"835-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of dosimetric parameters for predicting radiation\u2010induced cataract in paediatric patients"],"prefix":"10.1111","volume":"68","author":[{"given":"Siriphan","family":"Leangcharoensap","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kullathorn","family":"Thephamongkhol","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putthipong","family":"Chanwichu","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teeradon","family":"Treechairusame","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Suntornpong","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-905X","authenticated-orcid":false,"given":"Warissara","family":"Rongthong","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14276.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12598"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.6088"},{"key":"e_1_2_7_5_1","first-page":"71","article-title":"Optical correction of aphakia in children","volume":"9","author":"Baradaran\u2010Rafii A","year":"2014","journal-title":"J Ophthalmic Vis Res"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.12.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.07.049"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.01.016"},{"key":"e_1_2_7_10_1","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 [online].2017. 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