{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T05:05:35Z","timestamp":1736139935384,"version":"3.32.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in UM patients undergoing HAIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis with 60 UM patients (29 females, mean age: 61.6\u2009\u00b1\u200912.1\u2009years) with hepatic metastases was performed. Histomorphological patterns in metastases were analysed and classified as either predominant spindle cell or epithelioid pattern. mOS between both patient groups was analysed using Kaplan\u2013Meier curves and the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 73.3% (44\/60) of the metastases, a predominant epithelioid pattern, in 21.7% (13\/60) a predominant spindle cell pattern, and in 5% (3\/60) other patterns were found. No significant differences between patients with an epithelioid (mOS: 14.2\u2009months, 95% CI: 8.8\u201319.6) and a spindle cell pattern (mOS: 14.4\u2009months, 95% CI: 4.3\u201324.5) were detected by the log\u2010rank test, \u03c7<jats:sup>2<\/jats:sup>(2)\u2009=\u20090.22, <jats:italic>P<\/jats:italic>\u2009=\u20090.881.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Histomorphological patterns of UM metastases do not seem to be a predictor for mOS in UM patients undergoing HAIC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13783","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:03:41Z","timestamp":1727183021000},"page":"862-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy?"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-4166","authenticated-orcid":false,"given":"Hannah L","family":"Steinberg\u2010Vorhoff","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia C","family":"Ting","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Zensen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes M","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine University Medical Center Mannheim, Heidelberg University  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Richly","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sarcoma Center, West German Cancer Center University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Gr\u00fcneisen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens T","family":"Siveke","sequence":"additional","affiliation":[{"name":"Institute for Developmental Cancer Therapeutics, West German Cancer Center University Hospital Essen  Essen Germany"},{"name":"Division of Solid Tumor Translational Oncology German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center, DKFZ  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens M","family":"Theysohn","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-7679","authenticated-orcid":false,"given":"Benedikt M","family":"Schaarschmidt","sequence":"additional","affiliation":[{"name":"Department of 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