{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:50:16Z","timestamp":1791219016635,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mepitel film decreases the severity of radiation dermatitis in breast cancer patients, but its application is resource\u2010intensive. Many departments therefore use StrataXRT, a gel that patients apply themselves. We compared the protective effects of Mepitel film and StrataXRT on radiation dermatitis during and immediately after radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This phase III multicentre randomised intra\u2010patient\u2010controlled clinical trial recruited breast cancer patients receiving radiation therapy following mastectomy in three New Zealand Hospitals. Lateral and medial aspects of the chest wall were randomised to either Mepitel film or StrataXRT. Overall skin reaction severity was measured using RISRAS and RTOG once a week during treatment and for 4\u2009weeks after treatment completion. The primary outcome was moist desquamation (with a non\u2010inferiority margin of 7.5%); secondary outcomes were overall skin reaction severity, patient tolerability, satisfaction and cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between June 2021 and May 2024, 93 patients were recruited, and 80 patients completed the trial. The absolute difference in moist desquamation rates was 6% lower under Mepitel film (<jats:italic>p<\/jats:italic>\u2009=\u20090.413, 95% CI \u20105%, 18%). Overall skin reaction severity was significantly lower for Mepitel film (Researcher RISRAS: <jats:italic>p<\/jats:italic>\u2009=\u20090.022; RTOG: <jats:italic>p<\/jats:italic>\u2009=\u20090.011). Mepitel film was cheaper to apply but was less well tolerated, with poor skin adherence being an issue for many patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study did not show non\u2010inferiority for StrataXRT; overall skin reaction severity and costs were significantly lower under Mepitel film; however, StrataXRT was better tolerated.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> ACTRN12621000124831<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13850","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T10:33:12Z","timestamp":1744626792000},"page":"440-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mepitel Film Versus <scp>StrataXRT<\/scp> in Managing Radiation Dermatitis in an Intra\u2010Patient Controlled Clinical Trial of 80 Postmastectomy Patients"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-2513","authenticated-orcid":false,"given":"Patries","family":"Herst","sequence":"first","affiliation":[{"name":"Department of Radiation Therapy University of Otago  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"van Schalkwyk","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service, Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Baker","sequence":"additional","affiliation":[{"name":"Regional Cancer Treatment Service, Palmerston North Hospital  Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Thyne","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service, Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Dunne","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service, Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Moore","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service, Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Jackson","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service, Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendal","family":"Beaven","sequence":"additional","affiliation":[{"name":"Wellington Blood and Cancer Centre, Wellington Hospital  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Rutten","sequence":"additional","affiliation":[{"name":"Wellington Blood and Cancer Centre, Wellington Hospital  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"McKee","sequence":"additional","affiliation":[{"name":"Wellington Blood and Cancer Centre, Wellington Hospital  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Willink","sequence":"additional","affiliation":[{"name":"Biostatistics Group University of Otago  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-1951","authenticated-orcid":false,"given":"Melissa","family":"James","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service, Christchurch Hospital  Christchurch New Zealand"},{"name":"Department of Medicine, Christchurch Hospital University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010023\u201006986\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.01.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4172\/1948-5956.1000166"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170298"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmrs.397"},{"issue":"5","key":"e_1_2_10_9_1","first-page":"1","article-title":"Reduction of the Skin\u2010Effect Dose of IMRT Plan for Patients With Cancer in Pelvic Region","volume":"18","author":"Bui Vinh Q.","year":"2023","journal-title":"Molecular and Clinical Oncology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101886"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00067-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmrs.46"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tipsro.2018.05.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01873"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07982-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjon.2024.100530"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.07.023"},{"issue":"2","key":"e_1_2_10_18_1","first-page":"293","article-title":"The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation\u2010Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial","volume":"13","author":"Omidvari S.","year":"2022","journal-title":"Middle East Journal of Cancer"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11790"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.07.014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201008190\u20108"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<891::AID-SIM780>3.0.CO;2-B"},{"key":"e_1_2_10_23_1","article-title":"StrataXRT and Mepitel Film for Preventing Postmastectomy Acute Radiation Dermatitis in Breast Cancer: An Intrapatient Noninferiority Randomized Clinical Trial","author":"Lee S. F.","year":"2024","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-08205-4"}],"updated-by":[{"DOI":"10.1111\/1754-9485.70017","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000}}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T10:46:25Z","timestamp":1750243585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1754-9485.13850"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13850","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2024-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}