{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:27:19Z","timestamp":1750307239973,"version":"3.41.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pelvic examination is a routine component of post\u2010treatment surveillance for endometrial cancer, supported by global guidelines. However, there is no evidence of oncological or quality\u2010of\u2010life benefit, with data suggesting associated discomfort and potential psychological harm. We evaluate the value of routine pelvic examination in follow\u2010up protocols after adjuvant radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed all patients receiving adjuvant radiation therapy for endometrial carcinoma across two combined cancer services between January 2017 and December 2022. All stages and histological subtypes were eligible. At least 12\u2009months of documented follow\u2010up was required. Patients were stratified by FIGO stage (2009 and 2023) and ESGO\/ESTRO risk group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and sixty\u2010four of 395 patients met inclusion criteria, with a median follow\u2010up of 34\u2009months. Whilst demographics were widely distributed, the most common features included endometrioid histology (76.5%), FIGO 2023 stage II (48.5%) and ESGO\/ESTRO high\u2010risk (36.7%).<\/jats:p><jats:p>Disease recurrence was identified in 41 patients (15.5%). Only four patients had isolated local recurrence, with most also having distant disease at detection. Only three patients had asymptomatic recurrence found on examination (1.1% of cohort), with only one proceeding to salvage therapy (0.4% of cohort). As expected, higher\u2010risk groups were associated with worse overall survival (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found routine pelvic examination following adjuvant radiation therapy for endometrial cancer results in low recurrence detection rates, with salvageable local recurrences being rare. We advocate for the omission of routine pelvic examination from follow\u2010up protocols for patients receiving adjuvant radiation therapy, with either clinic\u2010based or telephone\u2010based follow\u2010up being offered on a risk\u2010stratified basis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13864","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T18:25:16Z","timestamp":1746642316000},"page":"531-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of Routine Pelvic Examination in the Follow\u2010Up of Patients Receiving Adjuvant Radiation Therapy for Endometrial Cancer: An Australian Tertiary\u2010Centre Experience"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-999X","authenticated-orcid":false,"given":"M. C.","family":"Knox","sequence":"first","affiliation":[{"name":"Radiation Oncology Network Western Sydney Local Health District  Sydney New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-3131","authenticated-orcid":false,"given":"A.","family":"Salkeld","sequence":"additional","affiliation":[{"name":"Radiation Oncology Network Western Sydney Local Health District  Sydney New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-6326","authenticated-orcid":false,"given":"A.","family":"Brand","sequence":"additional","affiliation":[{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Herbst","sequence":"additional","affiliation":[{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5301-0079","authenticated-orcid":false,"given":"J.","family":"Chard","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0253-0895","authenticated-orcid":false,"given":"N.","family":"Thiruthaneeswaran","sequence":"additional","affiliation":[{"name":"Radiation Oncology Network Western Sydney Local Health District  Sydney New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.4438"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2022.08.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.01.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101438.2007.00839.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.03.047"},{"volume-title":"Gynaecological Cancer: A Guide to Clinical Practice in NSW","year":"2019","author":"Gynaecological Oncology Network","key":"e_1_2_10_7_1"},{"volume-title":"Optimal Care Pathway for Women With Endometrial Cancer","year":"2021","author":"Cancer Council Victoria and Department of Health Victoria","key":"e_1_2_10_8_1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00471"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102019\u2010001176"},{"key":"e_1_2_10_11_1","unstructured":"WSLHD Department of Gynaecological Oncology \u201cAnnual Report 2023: Department of Gynaecological Oncology \u201d2024."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14923"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102020\u2010002230"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102021\u2010002903"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.02.011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181e2abcc"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090\u20108258(22)01338\u20105"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1745\u20107599.12020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.13574"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150132721992195"},{"volume-title":"Uterine Neoplasms (Version 1.2024)","year":"2024","author":"National Comprehensive Cancer Network","key":"e_1_2_10_21_1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.05.009"},{"volume-title":"NZGCG Follow Up Recommendations for Endometrial and Cervical Cancer","year":"2015","author":"New Zealand Gynaecological Cancer Group","key":"e_1_2_10_23_1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010022\u201002799\u20107"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.11.423"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100774"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2020.31.e18"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102020\u2010001929"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102022\u2010004039"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30020173"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010021\u201001128\u20101"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102346"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875\u2010023\u201002032\u20106"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T10:46:31Z","timestamp":1750243591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1754-9485.13864"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13864","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"type":"print","value":"1754-9477"},{"type":"electronic","value":"1754-9485"}],"subject":[],"published":{"date-parts":[[2025,5,7]]},"assertion":[{"value":"2024-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}