{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:10:59Z","timestamp":1782439859358,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Prostate cancer is a prevalent malignancy with rising incidence rates globally. High\u2010intensity focused ultrasound (HIFU) is a promising, minimally invasive treatment for localised prostate cancer. However, recurrence following HIFU, indicated by rising PSA levels or imaging\u2010confirmed local recurrence, remains a concern. Salvage radiotherapy is a potential treatment for recurrent prostate cancer post\u2010HIFU, but evidence on its efficacy and safety is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective study evaluated eight patients with localised prostate cancer who underwent salvage radiotherapy following HIFU failure. Salvage treatment consisted of external beam radiation therapy (EBRT), delivered either as conventional fractionation (76\u2009Gy in 38 daily fractions) or stereotactic ablative radiotherapy (36.25\u201340\u2009Gy in five alternate\u2010day fractions). Outcomes assessed included prostate\u2010specific antigen (PSA) response, biochemical progression\u2010free survival (bPFS), overall survival (OS) and treatment\u2010related toxicity profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All eight patients experienced a significant decline in PSA levels, with no biochemical failures observed during a median follow\u2010up of 72.4\u2009months. The 5\u2010year biochemical failure\u2010free survival and overall survival rates were 100%. Among the eight patients, 6 (75%) had Grade 2 or lower genitourinary toxicity, and 5 (62.5%) had Grade 2 or lower gastrointestinal toxicity, with no Grade 3 or higher adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Salvage EBRT after HIFU failure provides durable disease control with manageable side effects. Further research with larger cohorts is needed to refine treatment strategies for recurrent prostate cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.70009","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T06:32:46Z","timestamp":1755325966000},"page":"681-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Salvage Radiation Therapy for Localised Prostate Cancer Recurrence Following High\u2010Intensity Focused Ultrasound (<scp>HIFU<\/scp>) Failure"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-1828","authenticated-orcid":false,"given":"Atsuto","family":"Katano","sequence":"first","affiliation":[{"name":"Department of Radiology The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo 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