{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:10:36Z","timestamp":1791166236295,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to assess pelvic organ motion and volume changes during long\u2010course radiation therapy (LCRT) for anorectal cancer and propose an optimal planning target volume (PTV) margin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective study analysed 526 daily cone\u2010beam computed tomography (CBCT) from 22 patients with anorectal cancer undergoing LCRT. Patients followed a bladder\u2010filling protocol by drinking water before treatment. The bladder, rectum and mesorectum were delineated on planning CT and CBCTs. PTV margins were calculated using the van Herk formula, and margins to cover 95% interfractional motion were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bladder volume exhibited the higher variability (mean\u2009\u00b1\u2009standard deviations, 271.3\u2009\u00b1\u2009130.5\u2009mL), compared to the mesorectum (111.3\u2009\u00b1\u200926.2\u2009mL) and rectum (50.6\u2009\u00b1\u200915.6\u2009mL). Mesorectum motion showed no significant correlation with bladder volume changes but was significantly associated with rectal volume (<jats:italic>r<\/jats:italic>\u2009=\u20090.566; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 in the superior mesorectum). Anterior mesorectum motion was larger compared to other directions, particularly in the superior region, with systematic and random variations of 4.4 and 3.5\u2009mm. Using the van Herk formula, PTV margins for the anterior mesorectum were 5.8, 4.9, and 3.3\u2009mm for the superior, middle and inferior regions, respectively. Similarly, margins to cover 95% interfractional movement extended up to 6.7\u2009mm in the superior\u2013anterior region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bladder volume varied significantly during LCRT, while mesorectum motion was influenced by rectal volume changes. A 5\u2010mm PTV margin was sufficient for the mid to lower mesorectum, with a larger 7\u2010mm margin needed for the superior\u2013anterior mesorectum. Incorporating 95% interfractional motion coverage further refined these margin recommendations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.70022","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T09:51:37Z","timestamp":1758102697000},"page":"707-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantifying Interfractional Motion in Patients With Anorectal Cancer During Radiotherapy and Recommendations of Optimal Planning Target Volume Margins"],"prefix":"10.1111","volume":"69","author":[{"given":"Ye Jin","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmoon","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-0174","authenticated-orcid":false,"given":"Jin\u2010hong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.05.071"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2013.31.1.41"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.04.022"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.05.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.07.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-010-2105-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.08.016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.08.070"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.058"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.07.017"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrz092"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.11.011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02753-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.02.032"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00456"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semradonc.2003.10.003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.076"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.01.042"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02079-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02193-1"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T07:07:32Z","timestamp":1759475252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/1754-9485.70022"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.70022","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}