{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:13:08Z","timestamp":1773004388559,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This retrospective single\u2010institution study evaluated the safety, efficacy and durability of stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN) and related facial pain syndromes\u2014including TN1, TN2, multiple sclerosis (MS) associated\u2010TN and atypical facial pain (AFP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 192 patients treated with Gamma Knife SRS between 2015 and 2022 at Australia's only publicly funded GK centre. Outcomes included Barrow Neurological Institute (BNI) pain scores, time to response and relapse. Kaplan\u2013Meier and Cox regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 5\u2009years. Treatment response occurred in 88.5%, with a relapse rate of 30%. Faster response was seen with 85\u2009Gy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and prior SRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). MS\u2010related TN relapsed earlier than vascular, tumour, idiopathic or stroke\u2010related causes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) and TN1\/TN2\/AFP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). On multivariable analysis, prior balloon compression (HR 3.02, 95% CI 1.07\u20138.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) and 85\u2009Gy (HR 2.07, 95% CI 1.29\u20133.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) were associated with faster response. Patients with vascular TN (HR 0.32, 95% CI 0.13\u20130.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), tumour\/stroke\/idiopathic aetiology (HR 0.36, 95% CI 0.14\u20130.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) had utilised prior medication only (HR 0.18, 95% CI 0.06\u20130.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and had undergone prior MVD alone (HR 0.11, 95% CI 0.03\u20130.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) were less likely to relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SRS remains a valuable option for refractory facial pain, including redo SRS in select patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70062","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:39:41Z","timestamp":1767627581000},"page":"205-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Radiosurgical Treatment of Trigeminal Neuralgia and Related Facial Pain Syndromes: The Australian Gamma Knife Experience"],"prefix":"10.1111","volume":"70","author":[{"given":"Ishwarya","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad Bin","family":"Anis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Department of Neurosurgery Shaukat Khanum Memorial Cancer Hospital and Research Centre  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hamza","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Scott","sequence":"additional","affiliation":[{"name":"QCIF Biostatistics, Institute for Molecular Bioscience The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Pinkham","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Neurosurgical Interventions for the Treatment of Classical Trigeminal Neuralgia","volume":"9","author":"Zakrzewska J. 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