{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:31:39Z","timestamp":1789072299011,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increased breast density is associated with increased breast cancer risk, particularly interval\u2010detected cancers. This study describes interval cancer detection rates by breast density notification status and timing of diagnosis (0\u201312\u2009months vs. 13\u201324\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>401,254 screening records for 235,333 clients attending a population\u2010based screening program in 2016\u20132019 were extracted from the BreastScreen Western Australia database. Crude and age\u2010standardised interval cancer rates (ASR), aggregated over three\u2010year periods, were calculated per 10,000 client\u2010years and reported by breast density notification status, screening round, and timing of diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, interval cancer rates were 2\u20136 times higher in clients notified they had dense breasts compared to those who were not flagged as having dense breasts. The 2016\u20132018 ASRs were higher in the first year (vs second year) for clients notified they had dense breasts (ASRs: 28.2 (95% CI: 12.9\u201366.0) vs 20.6 (95% CI: 13.2\u201355.8) per 10,000 client\u2010years, respectively), particularly notified clients screening for the first time (ASRs: 32.7 (95% CI: 6.9\u2013111.2) vs 18.2 (95% CI: 5.9\u201392.0), respectively). The corresponding rates for 2017\u20132019 showed a similar trend but of lesser magnitude (ASRs: 17.6 (95% CI: 12.9\u201334.2) vs 15.7 (95% CI: 11.0\u201335.5) for 0\u201312 vs 13\u201324\u2009months, respectively), regardless of screening round.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interval cancer rates were at least similar or higher in the first 12\u2009months compared to 13\u201324\u2009months post screening for clients notified they had dense breasts, contrary to national reports of interval cancer detection rates. The clinical implications are two\u2010fold: performance metrics for screening programs that notify women of their breast density may need refinement, namely interval cancer rate targets within 0\u201312\u2009months, and breast density notification could lead to earlier diagnoses of interval\u2010detected breast cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70067","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:08:11Z","timestamp":1769000891000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Breast Density Notification on Interval Cancer Rates"],"prefix":"10.1111","volume":"70","author":[{"given":"Jennifer","family":"Stone","sequence":"first","affiliation":[{"name":"School of Population and Global Health, University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Marriott","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Orellana","sequence":"additional","affiliation":[{"name":"BreastScreen Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Lee","sequence":"additional","affiliation":[{"name":"BreastScreen Western Australia  Perth Western Australia Australia"},{"name":"Sir Charles Gardiner Hospital  Perth Western Australia Australia"},{"name":"King Edward Memorial Hospital  Perth Western Australia Australia"},{"name":"Medical School, University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Porter","sequence":"additional","affiliation":[{"name":"BreastScreen Western Australia  Perth Western Australia Australia"},{"name":"Sir Charles Gardiner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-1175"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7227"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab016"},{"key":"e_1_2_10_8_1","unstructured":"BreastScreen Australia \u201cBreastScreen Australia\u2014Position Statement on Breast Density and Screening \u201dhttps:\/\/www.health.gov.au\/resources\/publications\/breastscreen\u2010australia\u2010position\u2010statement\u2010on\u2010breast\u2010density\u2010and\u2010screening?language=en2025."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903986"},{"key":"e_1_2_10_10_1","unstructured":"Australia B \u201cBreast Density GP Guidance \u201dhttps:\/\/www.health.gov.au\/our\u2010work\/breastscreen\u2010australia\u2010program\/health\u2010professionals\/breast\u2010density\u2010information\u2010for\u2010gps2025."},{"issue":"2","key":"e_1_2_10_11_1","first-page":"29","article-title":"What Do Women Do After Being Told They Have Dense Breasts?","volume":"32","author":"Darcey E.","year":"2020","journal-title":"Health Promotion Journal of Australia"},{"key":"e_1_2_10_12_1","unstructured":"Australian Institute of Health and Welfare \u201cBreastScreen Australia Monitoring Report 2023 \u201d(2023)."},{"key":"e_1_2_10_13_1","volume-title":"RANZCR Breast Imaging Group (BIG) General Meeting Abstracts. RANZCR Breast Imaging Group (BIG) General Meeting","author":"Royal Australian New Zealand College of Radiologists","year":"2025"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970415)16:7<791::AID-SIM500>3.0.CO;2-#"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1258\/096914106778440572"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anzjph.2025.100240"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6883"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.70067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:36:20Z","timestamp":1772994980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/1754-9485.70067"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.70067","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}