{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:48:41Z","timestamp":1775904521136,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evaluating therapeutic efficacy in colorectal malignancies presents significant challenges when relying solely on conventional anatomical imaging approaches. The primary aim of this prospective study was to compare the diagnostic effectiveness of integrated positron emission tomography\u2013computed tomography (PET\u2010CT) and diffusion\u2010weighted magnetic resonance imaging (DWI\u2010MRI) for monitoring chemotherapy response in patients with colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective comparative analysis included 132 histologically confirmed patients with colorectal cancer planned for first\u2010line chemotherapy (FOLFOX, FOLFIRI, or CAPOX). Twelve of 132 patients left the study during follow\u2010up. Patients underwent baseline PET\u2010CT and DWI\u2010MRI exams, with repeat scans at 3, 6, and 12\u2009weeks post\u2010treatment. Response assessment used RECIST v1.1 for morphology, PERCIST v1.0 for metabolism, and quantitative apparent diffusion coefficient (ADC) analysis for DWI\u2010MRI. Survival outcomes, correlation studies, and receiver operating characteristic curve analysis were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients had a mean age of 62.7\u2009\u00b1\u20099.6\u2009years, with 51.7% men. PET\u2010CT indicated a 36.0%\u2009\u00b1\u200925.3% SUVmax reduction, and DWI\u2010MRI showed a 51.4%\u2009\u00b1\u200942.1% ADC rise at 12\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A significant negative association (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.732,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) occurred between SUVmax and ADC values. DWI\u2010MRI outperformed PET\u2010CT in terms of diagnostic performance, with an AUC of 0.887 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.156), a sensitivity of 90.9% compared to 84.4%, and a specificity of 76.7% compared to 72.1%. Concordant responders demonstrated better progression\u2010free survival (18.0 vs. 4.8\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both PET\u2010CT and DWI\u2010MRI demonstrate excellent diagnostic performance for assessing chemotherapy response, with DWI\u2010MRI showing marginal superiority in sensitivity and predictive accuracy, supporting its use as a radiation\u2010free alternative for treatment monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70079","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:59:57Z","timestamp":1772960397000},"page":"272-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Chemotherapy Response in Colorectal Cancer Using PET\u2010CT Versus DWI\u2010MRI"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0347-2560","authenticated-orcid":false,"given":"Jawad Ali","family":"Memon","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology Peoples University of Medical and Health Sciences for Women (PUMHSW)  Nawabshah Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3795-7028","authenticated-orcid":false,"given":"Zubair Ali","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Oncology King Faisal Specialist Hospital &amp; Research Centre  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1570-7703","authenticated-orcid":false,"given":"Mohammad Sibtain","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Oncology Peoples University of Medical and Health Sciences for Women (PUMHSW)  Nawabshah Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1235-3311","authenticated-orcid":false,"given":"Uzma","family":"Malik","sequence":"additional","affiliation":[{"name":"Kuwait Cancer Control Center  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4370-2996","authenticated-orcid":false,"given":"Mohammad Saleh","family":"Chandio","sequence":"additional","affiliation":[{"name":"Department of Oncology Gambat Institute of Medical Sciences (GIMS)  Gambat Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092025"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-024-00698-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3053"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-023-00961-x"},{"key":"e_1_2_12_6_1","unstructured":"A. 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