{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:04:03Z","timestamp":1779696243313,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcoidosis is a multisystem granulomatous disease that commonly affects the lungs and intrathoracic lymph nodes. On imaging, characteristic patterns of lymphadenopathy, such as the lambda sign on fluorodeoxyglucose positron emission tomography (FDG PET), are considered suggestive of the disease and can assist in differentiating sarcoidosis from differential diagnoses. FDG PET\/CT is increasingly used to assess disease extent, identify extrapulmonary involvement, guide biopsy and monitor inflammatory activity. The prevalence and imaging characteristics of the lambda sign and periportal\/portocaval lymphadenopathy, termed the 1\u20132\u20133\u20104 sign on FDG PET\/CT in sarcoidosis, remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was performed of patients with sarcoidosis who underwent FDG PET\/CT imaging at a tertiary centre in 2019. PET studies were assessed for the presence of the lambda sign and for FDG\u2010avid periportal and\/or portocaval lymph nodes. The frequency of the lambda and 1\u20132\u20133\u20104 sign, nodal distribution, and metabolic activity were analysed, including maximum standardised uptake values (SUVmax).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The lambda sign was identified in a substantial proportion of patients. FDG\u2010avid periportal and\/or portocaval lymph nodes were observed in a subset of cases, although only one patient demonstrated the complete 1\u20132\u20133\u20104 sign. Periportal and portocaval nodes showed FDG uptake comparable to intrathoracic nodal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FDG\u2010avid periportal and portocaval lymphadenopathy may occur alongside classic intrathoracic nodal patterns in sarcoidosis, although the complete 1\u20132\u20133\u20104 sign appears uncommon. Recognition of this imaging pattern on FDG PET\/CT may support diagnostic confidence in appropriate clinical contexts and help differentiate sarcoidosis from alternative causes of mediastinal and abdominal lymphadenopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70122","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:32:53Z","timestamp":1779694373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["1\u20132\u20133\u20104 Sign\n                    <scp>FDG PET<\/scp>\n                    Sign in Sarcoidosis"],"prefix":"10.1111","author":[{"given":"Luke","family":"Cassidy","sequence":"first","affiliation":[{"name":"Community and Oral Health \u2013 Hospital in the Home  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinuri","family":"Edirisinghe","sequence":"additional","affiliation":[{"name":"Gold Coast University Hospital  Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepinoud","family":"Firouzmand","sequence":"additional","affiliation":[{"name":"I\u2010MED Radiology Network  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Black","sequence":"additional","affiliation":[{"name":"I\u2010MED Radiology Network, PET and Nuclear Medicine Department The Wesley Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-6754","authenticated-orcid":false,"given":"David","family":"Wong","sequence":"additional","affiliation":[{"name":"I\u2010MED Radiology Network, PET and Nuclear Medicine Department The Wesley Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445\u20105994.2007.01365.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006\u20100865CI"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00610"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.19.21436"},{"key":"e_1_2_9_7_1","article-title":"Pulmonary Sarcoidosis: Spectrum of Imaging Findings","volume":"154","author":"Blana I.","year":"2017","journal-title":"Hellenic Journal of Radiology"},{"issue":"12","key":"e_1_2_9_8_1","first-page":"1909","article-title":"Recognition of Distinctive Patterns of Gallium\u201067 Distribution in Sarcoidosis","volume":"31","author":"Sulavik S. B.","year":"1990","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972\u20103919.152975"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.02.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040766"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2025.102054"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.71557"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.70122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:32:54Z","timestamp":1779694374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":12,"alternative-id":["10.1111\/1754-9485.70122"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.70122","archive":["Portico"],"relation":{},"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2026-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1754-9485.70122"}}