{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:09:02Z","timestamp":1788872942283,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Stabilised hyaluronic acid (sHA) gel can be used as a breast cancer tumour bed marker. This study aimed to assess the gel on post\u2010treatment surveillance mammography (MMG) and breast ultrasound (USS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent breast\u2010conserving surgery and adjuvant radiotherapy, with sHA gel markers (0.3\u20130.5\u2009mL drops) in breast tissue had their routine 1\u2010 and 2\u2010year post\u2010treatment MMG and USS undergo central review by one experienced radiologist. The central review questionnaire included whether the gel was visible, description if visible, and whether it impacted diagnostic assessment of the images using a 5\u2010point Likert scale. The images were also standardly reported by radiologists who were blinded to the gel history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 33 patients eligible for evaluation, sHA gel was visible on the 1\u2010year post\u2010treatment MMG in 3% of patients, described as well circumscribed nodules adjacent to the surgical scar. sHA gel was visible on the 1\u2010year post\u2010treatment USS in 38% of patients, described as simple round cystic lesions near the surgical bed. sHA gel was still visible on the same patient's 2\u2010year post\u2010treatment MMG (3%) and was visible on the 2\u2010year post\u2010treatment USS in 19% of patients. In all cases, the gel was rated \u2018unlikely\u2019 or \u2018very unlikely\u2019 to impair diagnostic assessment of the images and did not lead to any additional investigations. The blinded radiologists reported the gel as non\u2010suspicious appearing cysts without clinical concern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sHA gel used as breast tumour bed marker was not visible in most patients' post\u2010treatment MMG and USS and did not affect diagnostic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1754-9485.70149","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:34:25Z","timestamp":1788870865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Appearance of Stabilised Hyaluronic Acid Gel on Routine Surveillance Breast Imaging When Used to Mark the Post\u2010Lumpectomy Tumour Bed in Breast Cancer"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-1167","authenticated-orcid":false,"given":"Janice","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-3746","authenticated-orcid":false,"given":"Michael","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Clayton Victoria Australia"},{"name":"Genesis Care, Ringwood Private Hospital  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tacey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-3848","authenticated-orcid":false,"given":"Jenny","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0680","authenticated-orcid":false,"given":"Sweet Ping","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Foroudi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-7775","authenticated-orcid":false,"given":"Eddie","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Radiology and Molecular Imaging Therapy Austin Health  Heidelberg Victoria Australia"},{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.21037\/gs.2018.11.10","article-title":"Evolution of Radiotherapy Techniques in Breast Conservation Treatment","volume":"7","author":"Boyages J.","year":"2018","journal-title":"Gland Surgery"},{"issue":"7","key":"e_1_2_11_3_1","first-page":"e636","article-title":"Task Group 284 Report: Magnetic Resonance Imaging Simulation in Radiotherapy: Considerations for Clinical Implementation, Optimization, and Quality Assurance","volume":"48","author":"Glide\u2010Hurst C. 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